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XB-ART-28178
FEBS Lett 1987 Apr 20;2142:253-8.
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Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations.

Kurosaki T, Fukuda K, Konno T, Mori Y, Tanaka K, Mishina M, Numa S.


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The four kinds of subunits of the Torpedo californica nicotinic acetylcholine receptor have been produced in various combinations by injecting Xenopus oocytes with the corresponding subunit-specific mRNAs synthesized by transcription in vitro of the cloned cDNAs. Functional analysis suggests that association of the alpha-subunit with either the gamma- or the delta-subunit is a prerequisite for generating the conformation necessary for agonist binding. The acetylcholine receptor devoid of either the beta-, gamma- or delta-subunit exhibits weak channel activity.

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