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J Mol Evol
1987 Jan 01;252:107-15. doi: 10.1007/bf02101752.
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The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family.
Cooper DN, Gerber-Huber S, Nardelli D, Schubiger JL, Wahli W.
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Sequence data from regions of five vertebrate vitellogenin genes were used to examine the frequency, distribution, and mutability of the dinucleotide CpG, the preferred modification site for eukaryotic DNA methyltransferases. The observed level of the CpG dinucleotide in all five genes was markedly lower than that expected from the known mononucleotide frequencies. CpG suppression was greater in introns than in exons. CpG-containing codons were found to be avoided in the vitellogenin genes, but not completely despite the redundancy of the genetic code. Frequency and distribution patterns of this dinucleotide varied dramatically among these otherwise closely related genes. Dense clusters of CpG dinucleotides tended to appear in regions of either functional or structural interest (e.g., in the transposon-like Vi-element of Xenopus) and these clusters contained 5-methylcytosine (5 mC). 5 mC is known to undergo deamination to form thymidine, but the extent to which this transition occurs in the heavily methylated genomes of vertebrates and its contribution to CpG suppression are still unclear. Sequence comparison of the methylated vitellogenin gene regions identified C----T and G----A substitutions that were found to occur at relatively high frequencies. The predicted products of CpG deamination, TpG and CpA, were elevated. These findings are consistent with the view that CpG distribution and methylation are interdependent and that deamination of 5 mC plays an important role in promoting evolutionary change at the nucleotide sequence level.
Adams,
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Adams,
Increased G + C content of DNA stabilizes methyl CpG dinucleotides.
1984,
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CpG-rich islands and the function of DNA methylation.
,
Pubmed Bird,
Variable patterns of total DNA and rDNA methylation in animals.
1980,
Pubmed Bird,
DNA methylation and the frequency of CpG in animal DNA.
1980,
Pubmed Bird,
DNA methylation--how important in gene control?
,
Pubmed Bird,
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA.
1985,
Pubmed Bolden,
Primary DNA sequence determines sites of maintenance and de novo methylation by mammalian DNA methyltransferases.
1986,
Pubmed Brown,
Long-range restriction site mapping of mammalian genomic DNA.
,
Pubmed Bullock,
Dipeptide frequencies in proteins and the CpG deficiency in vertebrate DNA.
1972,
Pubmed Burch,
Chromatin structural transitions and the phenomenon of vitellogenin gene memory in chickens.
1986,
Pubmed Cooper,
DNA restriction fragment length polymorphisms and heterozygosity in the human genome.
1984,
Pubmed Cooper,
Eukaryotic DNA methylation.
1983,
Pubmed Cooper,
Variation in the DNA methylation pattern of expressed and nonexpressed genes in chicken.
1983,
Pubmed
,
Xenbase Cooper,
DNA methylation and CpG suppression.
1985,
Pubmed Cooper,
Unmethylated domains in vertebrate DNA.
1983,
Pubmed Coulondre,
Molecular basis of base substitution hotspots in Escherichia coli.
1978,
Pubmed Geiser,
Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin ii gene.
1983,
Pubmed Gerber-Huber,
In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated.
1983,
Pubmed
,
Xenbase Germond,
Evolution of vitellogenin genes: comparative analysis of the nucleotide sequences downstream of the transcription initiation site of four Xenopus laevis and one chicken gene.
1984,
Pubmed
,
Xenbase Grantham,
Codon catalog usage is a genome strategy modulated for gene expressivity.
1981,
Pubmed Hummel,
Characterization of highly and moderately repetitive 500 bp Eco RI fragments from Xenopus laevis DNA.
1984,
Pubmed
,
Xenbase JOSSE,
Enzymatic synthesis of deoxyribonucleic acid. VIII. Frequencies of nearest neighbor base sequences in deoxyribonucleic acid.
1961,
Pubmed Kay,
The 1723 element: a long, homogeneous, highly repeated DNA unit interspersed in the genome of Xenopus laevis.
1983,
Pubmed
,
Xenbase Li,
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene.
1985,
Pubmed Li,
Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications.
1984,
Pubmed McClelland,
Asymmetrical distribution of CpG in an 'average' mammalian gene.
1982,
Pubmed Meijlink,
Methylation of the chicken vitellogenin gene: influence of estradiol administration.
1983,
Pubmed Philipsen,
Expression-linked demethylation of 5-methylcytosines in the chicken vitellogenin gene region.
1985,
Pubmed Saluz,
Optimized genomic sequencing as a tool for the study of cytosine methylation in the regulatory region of the chicken vitellogenin II gene.
1986,
Pubmed Savatier,
Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee.
1985,
Pubmed Schubiger,
The Vi element. A transposon-like repeated DNA sequence interspersed in the vitellogenin locus of Xenopus laevis.
1985,
Pubmed
,
Xenbase Selker,
DNA methylation at asymmetric sites is associated with numerous transition mutations.
1985,
Pubmed Smith,
Statistical characterization of nucleic acid sequence functional domains.
1983,
Pubmed van der Ploeg,
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues.
1980,
Pubmed Vogel,
Non-randomness of base replacement in point mutation.
1972,
Pubmed Vogel,
Non-randomness of base replacement in point mutation.
2013,
Pubmed Vogel,
Higher frequencies of transitions among point mutations.
1977,
Pubmed Wahli,
Vitellogenesis and the vitellogenin gene family.
1981,
Pubmed
,
Xenbase Wahli,
Vitellogenin genes A1 and B1 are linked in the Xenopus laevis genome.
1982,
Pubmed
,
Xenbase Wahli,
Xenopus vitellogenin genes.
1985,
Pubmed
,
Xenbase Walker,
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.
1984,
Pubmed
,
Xenbase Walker,
Sequence homologies within the 5' end region of the estrogen-controlled vitellogenin gene in Xenopus and chicken.
1983,
Pubmed
,
Xenbase Wallace,
Vitellogenesis and oocyte growth in nonmammalian vertebrates.
1985,
Pubmed Wang,
Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA.
1982,
Pubmed Wang,
A human DNA-binding protein is methylation-specific and sequence-specific.
1986,
Pubmed Wang,
Identificiation, purification, and characterization of two distinct avian vitellogenins.
1980,
Pubmed Wigler,
The inheritance of methylation patterns in vertebrates.
1981,
Pubmed Wilks,
Isolation and fine structure organisation of an avian vitellogenin gene coding for the major estrogen-inducible mRNA.
1981,
Pubmed
,
Xenbase Wilks,
Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.
1982,
Pubmed Wolf,
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes.
,
Pubmed Youssoufian,
Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots.
,
Pubmed
