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EMBO J
1986 Dec 20;513:3571-7. doi: 10.1002/j.1460-2075.1986.tb04684.x.
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C-myc expression is dissociated from DNA synthesis and cell division in Xenopus oocyte and early embryonic development.
Godeau F, Persson H, Gray HE, Pardee AB.
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The combined use of a human c-myc probe and of an antibody raised against the human c-myc gene product demonstrated that the Xenopus cells contained a 2.5-kb c-myc transcript and synthesized a c-myc immunoreactive 65-kd polypeptide. In full-grown oocytes, p65c-myc was predominantly located in the nucleus. In non-dividing Xenopus oocytes c-myc mRNA was present at a steady-state level 10(4) times higher than that of growing somatic A6 cells. This very high level of c-myc transcript was reached early in oogenesis and remained constant thereafter. The rate of p65c-myc synthesis also reached high levels, but only in vitellogenic oocytes, suggesting a post-transcriptional control. Although the cell cycle is resumed at a very fast pace in developing embryos, no further increase in total embryonic content of c-myc RNA could be demonstrated up to the swimming tadpole stage. Furthermore, in embryos the rate of synthesis of p65c-myc decreased to a level markedly lower than that of cell cycle-arrested vitellogenic oocytes. This observation suggests that the function of the c-myc gene in the cell cycle may not be implicated directly in sustaining DNA synthesis or mitosis.
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,
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,
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,
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,
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Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
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,
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V-myc- and c-myc-encoded proteins are associated with the nuclear matrix.
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Rate of macromolecular synthesis through the cell cycle of the yeast Saccharomyces cerevisiae.
1978,
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Non-coordinated accumulation and synthesis of 5S ribonucleic acid by ovaries of Xenopus laevis.
1971,
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,
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1980,
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,
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,
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,
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Distribution of nuclear proteins during maturation of the Xenopus oocyte.
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,
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,
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
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,
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1984,
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,
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1973,
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An acidic protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei.
1980,
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,
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Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture.
1984,
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Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin.
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Pubmed Newport,
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1982,
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,
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,
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,
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,
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,
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,
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,
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Nuclear pore flow rate of ribosomal RNA and chain growth rate of its precursor during oogenesis of Xenopus laevis.
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,
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,
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,
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,
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