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We have isolated a Xenopus genomic clone (Xhox-1) that contains two homeoboxes, at least one of which is highly conserved in vertebrates. Two transcripts are derived from Xhox-1 and these are present from early in development through swimming tadpole stages. A detailed analysis of one of the genes shows that it is expressed maternally and that transcription from the zygotic genome begins at mid-gastrulation. Examination of exogastrula shows that the expression of these genes does not depend on neural induction. We have determined the DNA sequence of a Xhox-1 cDNA and this allows us to predict the complete sequence of a vertebrate homeobox protein. Synthetic mRNAs made from this cDNA are translated efficiently in Xenopus oocytes where the homeobox protein localizes to the oocytenucleus.
Akam,
The distribution of Ultrabithorax transcripts in Drosophila embryos.
1985, Pubmed
Akam,
The distribution of Ultrabithorax transcripts in Drosophila embryos.
1985,
Pubmed Beachy,
Segmental distribution of bithorax complex proteins during Drosophila development.
,
Pubmed Bonner,
Protein migration into nuclei. I. Frog oocyte nuclei in vivo accumulate microinjected histones, allow entry to small proteins, and exclude large proteins.
1975,
Pubmed
,
Xenbase BROWN,
RNA SYNTHESIS DURING THE DEVELOPMENT OF XENOPUS LAEVIS, THE SOUTH AFRICAN CLAWED TOAD.
1964,
Pubmed
,
Xenbase Carrasco,
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.
1984,
Pubmed
,
Xenbase Colberg-Poley,
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells.
,
Pubmed Colberg-Poley,
Clustered homeo boxes are differentially expressed during murine development.
1985,
Pubmed Davey,
Identification of the sequence responsible for the nuclear accumulation of the influenza virus nucleoprotein in Xenopus oocytes.
1985,
Pubmed
,
Xenbase Desplan,
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
,
Pubmed DiNardo,
Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein.
1985,
Pubmed Dolecki,
Poly(A)+ RNA metabolism during oogenesis in Xenopus laevis.
1979,
Pubmed
,
Xenbase Dworkin,
Mobilization of specific maternal RNA species into polysomes after fertilization in Xenopus laevis.
1985,
Pubmed
,
Xenbase Gurdon,
Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal.
1976,
Pubmed
,
Xenbase Gurdon,
Transcription of muscle-specific actin genes in early Xenopus development: nuclear transplantation and cell dissociation.
1984,
Pubmed
,
Xenbase Hafen,
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila.
,
Pubmed Hart,
Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.
1985,
Pubmed Hauser,
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
1985,
Pubmed Jackson,
A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.
,
Pubmed
,
Xenbase Joyner,
Comparative chromosome mapping of a conserved homoeo box region in mouse and human.
,
Pubmed Joyner,
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
1985,
Pubmed Kozak,
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
1986,
Pubmed Krieg,
Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs.
1985,
Pubmed
,
Xenbase Laughon,
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.
,
Pubmed Levine,
Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.
1984,
Pubmed McGinnis,
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.
,
Pubmed McGinnis,
A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
1984,
Pubmed McGinnis,
Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.
1984,
Pubmed Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed Mlodzik,
Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage.
1985,
Pubmed Müller,
A homeo-box-containing gene expressed during oogenesis in Xenopus.
1984,
Pubmed
,
Xenbase Newport,
A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.
1982,
Pubmed
,
Xenbase Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase Rabin,
Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes.
,
Pubmed
,
Xenbase Rebagliati,
Identification and cloning of localized maternal RNAs from Xenopus eggs.
1985,
Pubmed
,
Xenbase Regulski,
Homeo box genes of the Antennapedia and bithorax complexes of Drosophila.
1985,
Pubmed Rosbash,
Polyadenylic acid-containing RNA in Xenopus laevis oocytes.
1974,
Pubmed
,
Xenbase Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Sargent,
Differential gene expression in the gastrula of Xenopus laevis.
1983,
Pubmed
,
Xenbase Scott,
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
1984,
Pubmed Shepherd,
Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.
,
Pubmed
,
Xenbase Struhl,
Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes.
1985,
Pubmed Struhl,
Genes controlling segmental specification in the Drosophila thorax.
1982,
Pubmed Wakimoto,
Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster.
1984,
Pubmed Weiner,
A molecular analysis of fushi tarazu, a gene in Drosophila melanogaster that encodes a product affecting embryonic segment number and cell fate.
1984,
Pubmed White,
Protein products of the bithorax complex in Drosophila.
1984,
Pubmed Whiteway,
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.
1985,
Pubmed
