Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nucleotide sequence of the chicken 5-aminolevulinate synthase gene.
Maguire DJ, Day AR, Borthwick IA, Srivastava G, Wigley PL, May BK, Elliott WH.
???displayArticle.abstract???
5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken histone H2B gene and injected into the nuclei of Xenopus laevis oocytes.
Baty,
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters.
1984, Pubmed
Baty,
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters.
1984,
Pubmed Benoist,
The ovalbumin gene-sequence of putative control regions.
1980,
Pubmed Benton,
Screening lambdagt recombinant clones by hybridization to single plaques in situ.
1977,
Pubmed Borthwick,
Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor.
1985,
Pubmed Borthwick,
Purification of 5-aminolaevulinate synthase from liver mitochondria of chick embryo.
1983,
Pubmed Borthwick,
Molecular cloning of hepatic 5-aminolevulinate synthase.
1984,
Pubmed Breathnach,
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
1978,
Pubmed Breathnach,
Organization and expression of eucaryotic split genes coding for proteins.
1981,
Pubmed Chen,
The functional human dihydrofolate reductase gene.
1984,
Pubmed Crouse,
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.
1982,
Pubmed Deininger,
Random subcloning of sonicated DNA: application to shotgun DNA sequence analysis.
1983,
Pubmed Dodgson,
Isolation of the chicken beta-globin gene and a linked embryonic beta-like globin gene from a chicken DNA recombinant library.
1979,
Pubmed Dynan,
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.
,
Pubmed Everett,
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter.
1983,
Pubmed Granick,
The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals.
1966,
Pubmed Gunn,
Sequence homology at the 3'-termini of the four RNAs of alfalfa mosaic virus.
1980,
Pubmed Kao,
Isolation and chromosomal localization of unique DNA sequences from a human genomic library.
1982,
Pubmed Keller,
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.
1984,
Pubmed Kressmann,
Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis.
1978,
Pubmed
,
Xenbase Kwoh,
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase.
1984,
Pubmed Leong,
Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti.
1985,
Pubmed Levanon,
Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.
1985,
Pubmed Lewis,
Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype.
1985,
Pubmed Marshall,
Interpretation of the properties of chromatin extracts from mammalian nuclei.
1976,
Pubmed Max,
New twist to DNA methylation.
,
Pubmed McKnight,
Transcriptional control signals of a eukaryotic protein-coding gene.
1982,
Pubmed McKnight,
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region.
1981,
Pubmed
,
Xenbase Melton,
Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.
1984,
Pubmed Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed Mount,
A catalogue of splice junction sequences.
1982,
Pubmed Norrander,
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.
1983,
Pubmed Osborne,
5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription.
1985,
Pubmed Proudfoot,
3' non-coding region sequences in eukaryotic messenger RNA.
1976,
Pubmed Reynolds,
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.
1984,
Pubmed Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Srivastava,
Haem control in experimental porphyria. The effect of haemin on the induction of delta-aminolaevulinate synthase in isolated chick-embryo liver cells.
1980,
Pubmed Stein,
Pattern of methylation of two genes coding for housekeeping functions.
1983,
Pubmed Tykocinski,
CG dinucleotide clusters in MHC genes and in 5' demethylated genes.
1984,
Pubmed Valerio,
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
1985,
Pubmed Vigneron,
Effect of the 21-bp repeat upstream element on in vitro transcription from the early and late SV40 promoters.
1984,
Pubmed Wallace,
Multiple forms of mammalian deoxyribonucleic acid polymerase. An attempt to relate their interactions with nuclei and free deoxyribonucleic acid in vitro with their possible functions in vivo.
1971,
Pubmed Wolf,
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes.
,
Pubmed Yamamoto,
Isolation of recombinant cDNAs encoding chicken erythroid delta-aminolevulinate synthase.
1985,
Pubmed Yen,
Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes.
1984,
Pubmed
