Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
In Xenopus laevis oocytes, adenosine and other purinergic agonists induce a K+-conductance increase that is fully mimicked by intracellular application of cAMP. Acetylcholine suppresses the K+-conductance increase caused by adenosine, by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, or by intracellular injection of cAMP. This effect of acetylcholine is not mimicked by intracellular injection of Ca2+ or of the Ca-mobilizing agent inositol 1,4,5-trisphosphate. However, adenosine and cAMP responses are inhibited by 4 beta-phorbol 12,13-dibutyrate and 4 beta-phorbol 12-myristate 13-acetate. These results suggest that, in Xenopus oocytes, the muscarinic inhibition of purinergic and cAMP responses is mediated through the activation of the phospholipid-dependent, Ca-activated protein kinase (protein kinase C).
Beavo,
Identification and properties of cyclic nucleotide phosphodiesterases.
1982, Pubmed
Beavo,
Identification and properties of cyclic nucleotide phosphodiesterases.
1982,
Pubmed Berridge,
Inositol trisphosphate, a novel second messenger in cellular signal transduction.
,
Pubmed Cooper,
Bimodal regulation of adenylate cyclase.
1982,
Pubmed Dascal,
Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3',5'-cyclic monophosphate.
1984,
Pubmed
,
Xenbase Dascal,
Types of muscarinic response in Xenopus oocytes.
1980,
Pubmed
,
Xenbase DeRiemer,
Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C.
,
Pubmed Di Virgilio,
Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels.
,
Pubmed Dumont,
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
Pubmed
,
Xenbase Greengard,
Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters.
1976,
Pubmed Hartzell,
Mechanisms of slow postsynaptic potentials.
1981,
Pubmed Kandel,
Molecular biology of learning: modulation of transmitter release.
1982,
Pubmed Kuo,
Phospholipid-sensitive Ca2+-dependent protein kinase: a major protein phosphorylation system.
1984,
Pubmed Kupfermann,
Role of cyclic nucleotides in excitable cells.
1980,
Pubmed Kusano,
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane.
1982,
Pubmed
,
Xenbase Kusano,
Acetylcholine receptors in the oocyte membrane.
,
Pubmed
,
Xenbase Lotan,
Adenosine-induced slow ionic currents in the Xenopus oocyte.
1982,
Pubmed
,
Xenbase Meeker,
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.
1982,
Pubmed Miot,
The involvement of a calmodulin-dependent phosphodiesterase in the negative control of carbamylcholine on cyclic AMP levels in dog thyroid slices.
1983,
Pubmed Miot,
Characterization of the soluble cyclic nucleotide phosphodiesterases in Xenopus laevis oocytes. Evidence for a calmodulin-dependent enzyme.
1982,
Pubmed
,
Xenbase Moolenaar,
Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH.
,
Pubmed Nargeot,
Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP.
1983,
Pubmed Nemecek,
The role of cyclic nucleotide phosphodiesterase in the inhibition of cyclic AMP accumulation by carbachol and phosphatidate.
1982,
Pubmed Nishizuka,
The role of protein kinase C in cell surface signal transduction and tumour promotion.
,
Pubmed Oron,
Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes.
,
Pubmed
,
Xenbase Pace,
Influence of a tumor-promoting phorbol ester on the electrical response of B-cells to glucose and glyburide.
1984,
Pubmed Reuter,
Calcium channel modulation by neurotransmitters, enzymes and drugs.
,
Pubmed Richelson,
The molecular basis of neurotransmission at the muscarinic receptor.
1981,
Pubmed Rodbell,
The role of hormone receptors and GTP-regulatory proteins in membrane transduction.
1980,
Pubmed Sadler,
Progesterone inhibition of Xenopus oocyte adenylate cyclase is not mediated via the Bordetella pertussis toxin substrate.
1984,
Pubmed
,
Xenbase
