Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-29178
Nature 1985 Jun 01;3156021:641-7. doi: 10.1038/315641a0.
Show Gene links Show Anatomy links

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K.


???displayArticle.abstract???
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.

???displayArticle.pubmedLink??? 2989698
???displayArticle.link??? Nature


Species referenced: Xenopus