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This paper reports the inhibitory effects of calmidazolium (CDZ), a calmodulin inhibitor, on electrical uncoupling by CO2. Membrane potential and coupling ratio (V2/V1) are measured in two neighboring cells of Xenopus embryos (16 to 64 cell stage) for periods as long as 5.5 hr. Upon exposure to 100% CO2, control cells consistently uncouple even if the CO2 treatments are repeated every 15 min for 2.5 hr. CDZ (5 X 10(-8) - 1 X 10(-7) M) strongly inhibits uncoupling. The inhibition starts after 30, 50 and 60 min of treatment with 1 X 10(-7), 7 X 10(-8) and 5 X 10(-8) M CDZ, respectively, is concentration-dependent and partially reversible. In the absence of CO2, CDZ also improves electrical coupling. CDZ has no significant effect on membrane potential and nonjunctional membrane resistance. These data suggest that calmodulin or a calmodulin-like protein participates in the uncoupling mechanism.
Azarnia,
Cell junction and cycle AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type.
1981, Pubmed
Azarnia,
Cell junction and cycle AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type.
1981,
Pubmed Bean,
Beta-adrenergic modulation of calcium channels in frog ventricular heart cells.
,
Pubmed Blackmore,
Blockade of hepatic alpha-adrenergic receptors and responses by chlorpromazine and trifluoperazine.
1981,
Pubmed Estapé-Wainwright,
Cyclic nucleotides and calcium: their role in the control of cell communication in the heart.
1983,
Pubmed Flagg-Newton,
Cell junction and cyclic AMP: 1. Upregulation of junctional membrane permeability and junctional membrane particles by administration of cyclic nucleotide or phosphodiesterase inhibitor.
1981,
Pubmed Flagg-Newton,
Cell junction and cyclic AMP: II. Modulations of junctional membrane permeability, dependent on serum and cell density.
1981,
Pubmed Green,
Patch- and voltage-clamp analysis of cyclic AMP-stimulated inward current underlying neurone bursting.
,
Pubmed Hertzberg,
Liver gap junctions and lens fiber junctions: comparative analysis and calmodulin interaction.
1982,
Pubmed Kretsinger,
Crystallographic studies of calmodulin and homologs.
1980,
Pubmed Lees-Miller,
Drugs that block calmoduLin activity inhibit cell-to-cell coupling in the epidermis of Tenebrio molitor.
1982,
Pubmed Lehrer,
Fluorescence and conformational changes caused by proton binding to troponin C.
1974,
Pubmed Loewenstein,
Junctional intercellular communication: the cell-to-cell membrane channel.
1981,
Pubmed Obaid,
Cell-to-cell channels with two independently regulated gates in series: analysis of junctional conductance modulation by membrane potential, calcium, and pH.
1983,
Pubmed Peracchia,
Gap junction dynamics: reversible effects of divalent cations.
1980,
Pubmed Peracchia,
Structural correlates of gap junction permeation.
1980,
Pubmed Peracchia,
Is calmodulin involved in the regulation of gap junction permeability?
1983,
Pubmed
,
Xenbase Rink,
Free calcium in Xenopus embryos measured with ion-selective microelectrodes.
1980,
Pubmed
,
Xenbase Rose,
Intracellular pH, intracellular free Ca, and junctional cell-cell coupling.
1978,
Pubmed Schliwa,
Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins.
1981,
Pubmed Siegelbaum,
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.
1982,
Pubmed Spray,
Gap junctional conductance is a simple and sensitive function of intracellular pH.
1981,
Pubmed Spray,
Gap junctional conductance: comparison of sensitivities to H and Ca ions.
1982,
Pubmed Steiner,
The dependence of the molecular dynamics of calmodulin upon pH and ionic strength.
1983,
Pubmed Teranishi,
Dopamine modulates S-potential amplitude and dye-coupling between external horizontal cells in carp retina.
1983,
Pubmed Turin,
Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo.
1977,
Pubmed
,
Xenbase Turin,
Intracellular pH in early Xenopus embryos: its effect on current flow between blastomeres.
1980,
Pubmed
,
Xenbase Unwin,
Calcium-mediated changes in gap junction structure: evidence from the low angle X-ray pattern.
1983,
Pubmed Welsh,
Calmodulin binds to chick lens gap junction protein in a calcium-independent manner.
1982,
Pubmed Welsh,
Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.
1979,
Pubmed Welsh,
Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells.
1978,
Pubmed Wojtczak,
Influence of cyclic nucleotides on the internal longitudinal resistance and contractures in the normal and hypoxic mammalian cardiac muscle.
1982,
Pubmed
