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Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA.
Gourse RL, Gerbi SA.
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By hybridization and DNA sequencing, we have defined a specific region in Xenopus rDNA that is extremely conserved between Tetrahymena, a protozoan, and Xenopus, a vertebrate. This highly conserved region is found at the site where an intron has been shown to interrupt Tetrahymena rDNA [1,2], although we have not detected introns in genomic or cloned Xenopus rDNA. We have noted that the sequences corresponding to nuclear rDNA interon-flanking regions show an intriguing complementarity to tRNAiMet. This suggests possible models for tRNA-rRNA interactions in protein synthesis and/or rRNA splicing.
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6253905 ???displayArticle.pmcLink???PMC324180 ???displayArticle.link???Nucleic Acids Res ???displayArticle.grants???[+]
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