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Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, Kurup S, Glass DA, Patel MS, Shu W, Morrisey EE, McMahon AP, Karsenty G, Lang RA.
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Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophageWNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell death--in adjacent cells, and raise the possibility that they do so in many different cellular contexts.
Behrens,
Functional interaction of beta-catenin with the transcription factor LEF-1.
1996, Pubmed,
Xenbase
Behrens,
Functional interaction of beta-catenin with the transcription factor LEF-1.
1996,
Pubmed
,
Xenbase Bienz,
Linking colorectal cancer to Wnt signaling.
2000,
Pubmed Dann,
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
2001,
Pubmed
,
Xenbase DasGupta,
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
1999,
Pubmed Diez-Roux,
Macrophages induce apoptosis in normal cells in vivo.
1997,
Pubmed Diez-Roux,
Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression.
1999,
Pubmed Duffield,
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.
2005,
Pubmed Frade,
Microglia-derived nerve growth factor causes cell death in the developing retina.
1998,
Pubmed Gong,
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
2001,
Pubmed Goodwin,
Wnt signaling in the vasculature.
2002,
Pubmed He,
LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.
2004,
Pubmed Hoeppner,
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans.
2001,
Pubmed Huelsken,
New aspects of Wnt signaling pathways in higher vertebrates.
2001,
Pubmed
,
Xenbase Ishikawa,
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.
2001,
Pubmed
,
Xenbase Ito,
Regression of the hyaloid vessels and pupillary membrane of the mouse.
1999,
Pubmed Kato,
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.
2002,
Pubmed Lang,
Macrophages are required for cell death and tissue remodeling in the developing mouse eye.
1993,
Pubmed Lowe,
Intrinsic tumour suppression.
2004,
Pubmed McKercher,
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.
1996,
Pubmed Nusse,
WNT targets. Repression and activation.
1999,
Pubmed
,
Xenbase Perrimon,
Serpentine proteins slither into the wingless and hedgehog fields.
1996,
Pubmed Pollard,
Tumour-educated macrophages promote tumour progression and metastasis.
2004,
Pubmed Reddien,
Phagocytosis promotes programmed cell death in C. elegans.
2001,
Pubmed Savill,
A blast from the past: clearance of apoptotic cells regulates immune responses.
2002,
Pubmed Shu,
Wnt7b regulates mesenchymal proliferation and vascular development in the lung.
2002,
Pubmed Smith,
Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer.
1999,
Pubmed van Genderen,
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
1994,
Pubmed Willert,
Wnt proteins are lipid-modified and can act as stem cell growth factors.
2003,
Pubmed
,
Xenbase Xu,
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.
2004,
Pubmed
