Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
In contrast to the high degree of evolutionary conservation of the Vsx2/Chx10 gene family, vertebrate orthologues of Vsx1 display more divergent sequences and spatio-temporal expression patterns. Here, we report the cloning and expression pattern of Xenopus laevis Vsx1. Differently from the mouse and zebrafish orthologues, Xvsx1 transcription is activated at early neurula both in the evaginating eye vesicles and in the presumptive spinal cord. Compared to other retinal homeobox genes, such as Xrx1, Xsix3 and Xpax6, Xvsx1 is activated at a later stage; in addition, its anterior expression appears to be more specifically restricted to the retina. At tail bud stage, Xvsx1 expression in retinal progenitors persists, and its neural tube expression, which in the spinal cord corresponds to interneurons, progressively expands anteriorly reaching the midbrain-hindbrain boundary. During retinal neurogenesis, Xvsx1 expression is maintained in retinal progenitors and in a peripheral region of the ciliary marginal zone, while in the central retina, it becomes restricted to differentiated bipolar cells.
Briscoe,
Specification of neuronal fates in the ventral neural tube.
2001, Pubmed
Briscoe,
Specification of neuronal fates in the ventral neural tube.
2001,
Pubmed Burmeister,
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
1996,
Pubmed Casarosa,
Genetic analysis of metamorphic and premetamorphic Xenopus ciliary marginal zone.
2005,
Pubmed
,
Xenbase Chen,
Expression of Chx10 and Chx10-1 in the developing chicken retina.
2000,
Pubmed Chow,
Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1.
2004,
Pubmed Chow,
Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells.
2001,
Pubmed Ferda Percin,
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.
2000,
Pubmed Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase Helms,
Specification of dorsal spinal cord interneurons.
2003,
Pubmed Holt,
Lipofection of cDNAs in the embryonic vertebrate central nervous system.
1990,
Pubmed
,
Xenbase Huang,
Dual expression of GABA or serotonin and dopamine in Xenopus amacrine cells is transient and may be regulated by laminar cues.
1998,
Pubmed
,
Xenbase Lee,
Transcriptional networks regulating neuronal identity in the developing spinal cord.
2001,
Pubmed Liu,
Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer.
1994,
Pubmed Ohtoshi,
Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1.
2004,
Pubmed Passini,
Vsx-1 and Vsx-2: differential expression of two paired-like homeobox genes during zebrafish and goldfish retinogenesis.
1997,
Pubmed Semina,
Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues.
2000,
Pubmed Svendsen,
The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye.
1995,
Pubmed Zuber,
Specification of the vertebrate eye by a network of eye field transcription factors.
2003,
Pubmed
,
Xenbase
