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Mol Cell Biol
2006 Jun 01;2611:4277-87. doi: 10.1128/MCB.02470-05.
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Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein.
Jung MY, Lorenz L, Richter JD.
???displayArticle.abstract??? CPEB-mediated translation is important in early development and neuronal synaptic plasticity. Here, we describe a new eukaryotic initiation factor 4E (eIF4E) binding protein, Neuroguidin (Ngd), and its interaction with CPEB. In the mammalian nervous system, Ngd is detected as puncta in axons and dendrites and in growth cones and filopodia. Ngd contains three motifs that resemble those present in eIF4G, 4EBP, Cup, and Maskin, all of which are eIF4E binding proteins. Ngd binds eIF4E directly, and all three motifs must be deleted to abrogate the interaction between these two proteins. In injected Xenopus oocytes, Ngd binds CPEB and, most importantly, represses translation in a cytoplasmic polyadenylation element (CPE)-dependent manner. In Xenopus embryos, Ngd is found in both neural tube and neural crest cells. The injection of morpholino-containing antisense oligonucleotides directed against ngd mRNA disrupts neural tube closure and neural crest migration; however, the wild-type phenotype is restored by the injection of a rescuing ngd mRNA. These data suggest that Ngd guides neural development by regulating the translation of CPE-containing mRNAs.
Alarcon,
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.
2004, Pubmed,
Xenbase
Alarcon,
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.
2004,
Pubmed
,
Xenbase Andrésson,
The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway.
1998,
Pubmed
,
Xenbase Bagni,
Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.
2000,
Pubmed Barnard,
Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus.
2005,
Pubmed
,
Xenbase Barnard,
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
2004,
Pubmed
,
Xenbase Berger-Sweeney,
Reduced extinction of hippocampal-dependent memories in CPEB knockout mice.
2006,
Pubmed Blumberg,
An essential role for retinoid signaling in anteroposterior neural patterning.
1997,
Pubmed
,
Xenbase Brunet,
The transcription factor Engrailed-2 guides retinal axons.
2005,
Pubmed
,
Xenbase Campbell,
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.
2001,
Pubmed
,
Xenbase Cao,
Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation.
2002,
Pubmed
,
Xenbase Cho,
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.
2005,
Pubmed Dahanukar,
The Nanos gradient in Drosophila embryos is generated by translational regulation.
1996,
Pubmed Dahanukar,
Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila.
1999,
Pubmed Davis,
Protein synthesis within neuronal growth cones.
1992,
Pubmed Deitch,
An electron microscopic analysis of hippocampal neurons developing in culture: early stages in the emergence of polarity.
1993,
Pubmed de Moor,
The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes.
1997,
Pubmed
,
Xenbase de Moor,
Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA.
1999,
Pubmed
,
Xenbase Du,
Activity-dependent polyadenylation in neurons.
2005,
Pubmed
,
Xenbase Dubnau,
RNA recognition and translational regulation by a homeodomain protein.
1996,
Pubmed Gavis,
Localization of nanos RNA controls embryonic polarity.
1992,
Pubmed Gavis,
Translational regulation of nanos by RNA localization.
1994,
Pubmed Gingras,
Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
2001,
Pubmed Gingras,
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
1999,
Pubmed Groisman,
Translational control of the embryonic cell cycle.
2002,
Pubmed
,
Xenbase Haghighat,
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
1995,
Pubmed Hake,
CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation.
1994,
Pubmed
,
Xenbase Huang,
N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.
2002,
Pubmed
,
Xenbase Huber,
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
2000,
Pubmed Jung,
Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis.
2002,
Pubmed Jung,
Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k).
2000,
Pubmed Kang,
A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity.
1996,
Pubmed Mader,
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.
1995,
Pubmed Marcotrigiano,
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
1999,
Pubmed Mayor,
Induction of the prospective neural crest of Xenopus.
1995,
Pubmed
,
Xenbase McGrew,
Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.
1989,
Pubmed
,
Xenbase Mendez,
Translational control by CPEB: a means to the end.
2001,
Pubmed
,
Xenbase Mendez,
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
2000,
Pubmed
,
Xenbase Mendez,
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.
2000,
Pubmed
,
Xenbase Miller,
Cellular and molecular mechanisms of memory: the LTP connection.
1999,
Pubmed Murdoch,
Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
2001,
Pubmed Nakamura,
Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.
2004,
Pubmed Nelson,
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.
2004,
Pubmed Niessing,
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
2002,
Pubmed Portera-Cailliau,
Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia.
2003,
Pubmed Pyronnet,
Cell-cycle-dependent translational control.
2001,
Pubmed Richter,
Regulation of cap-dependent translation by eIF4E inhibitory proteins.
2005,
Pubmed Richter,
A developmentally regulated, nervous system-specific gene in Xenopus encodes a putative RNA-binding protein.
1990,
Pubmed
,
Xenbase Riechmann,
Axis formation during Drosophila oogenesis.
2001,
Pubmed Rivera-Pomar,
RNA binding and translational suppression by bicoid.
1996,
Pubmed Sarkissian,
Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.
2004,
Pubmed
,
Xenbase Scheetz,
NMDA receptor-mediated control of protein synthesis at developing synapses.
2000,
Pubmed Shin,
Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation.
2004,
Pubmed Smibert,
smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo.
1996,
Pubmed Smibert,
Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro.
1999,
Pubmed Sonenberg,
The mRNA 5' cap-binding protein eIF4E and control of cell growth.
1998,
Pubmed Stebbins-Boaz,
Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
1999,
Pubmed
,
Xenbase Stebbins-Boaz,
CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.
1996,
Pubmed
,
Xenbase Summerton,
Morpholino antisense oligomers: design, preparation, and properties.
1997,
Pubmed
,
Xenbase Tay,
The control of cyclin B1 mRNA translation during mouse oocyte maturation.
2000,
Pubmed Wang,
Nanos is the localized posterior determinant in Drosophila.
1991,
Pubmed Wells,
A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons.
2001,
Pubmed Wharton,
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos.
1991,
Pubmed Wilhelm,
Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz.
2003,
Pubmed Wu,
CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses.
1998,
Pubmed
,
Xenbase Zhang,
Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon.
2002,
Pubmed
,
Xenbase Zheng,
A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons.
2001,
Pubmed
