Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The direct developing anuran, Eleutherodactylus coqui, lacks a tadpole, hatching as a tiny frog. We investigated the role of the metamorphic trigger, thyroid hormone (TH), in this unusual ontogeny. Expression patterns of the thyroid hormone receptors, TRalpha and TRbeta, were similar to those of indirect developers. TRbeta mRNA levels increased dramatically around the time of thyroid maturation, when remodeling events reminiscent of metamorphosis occur. Treatment with the goitrogen methimazole inhibited this remodeling, which was reinitiated on cotreatment with TH. Despite their radically altered ontogeny, direct developers still undergo a TH-dependent metamorphosis, which occurs before hatching. We propose a new model for the evolution of anuran direct development.
Brown,
The role of thyroid hormone in zebrafish and axolotl development.
1997, Pubmed
Brown,
The role of thyroid hormone in zebrafish and axolotl development.
1997,
Pubmed Callery,
Opercular development and ontogenetic re-organization in a direct-developing frog.
2000,
Pubmed
,
Xenbase Callery,
Developmental regulation of the urea-cycle enzyme arginase in the direct developing frog Eleutherodactylus coqui.
1996,
Pubmed Cohen,
Biochemical differentiation during amphibian metamorphosis.
1970,
Pubmed Eliceiri,
Quantitation of endogenous thyroid hormone receptors alpha and beta during embryogenesis and metamorphosis in Xenopus laevis.
1994,
Pubmed
,
Xenbase Elinson,
Secondary coverage of the yolk by the body wall in the direct developing frog, Eleutherodactylus coqui: an unusual process for amphibian embryos.
1998,
Pubmed
,
Xenbase Elinson,
Leg development in a frog without a tadpole (Eleutherodactylus coqui).
1994,
Pubmed Furlow,
A set of novel tadpole specific genes expressed only in the epidermis are down-regulated by thyroid hormone during Xenopus laevis metamorphosis.
1997,
Pubmed
,
Xenbase Hanken,
Cranial ontogeny in the direct-developing frog, Eleutherodactylus coqui (Anura: Leptodactylidae), analyzed using whole-mount immunohistochemistry.
1992,
Pubmed Hanken,
Jaw muscle development as evidence for embryonic repatterning in direct-developing frogs.
1997,
Pubmed Helbing,
Sequential up-regulation of thyroid hormone beta receptor, ornithine transcarbamylase, and carbamyl phosphate synthetase mRNAs in the liver of Rana catesbeiana tadpoles during spontaneous and thyroid hormone-induced metamorphosis.
1992,
Pubmed
,
Xenbase Hughes,
The thyroid and the development of the nervous system in Eleutherodactylus martinicensis: an experimental study.
1966,
Pubmed Jennings,
Mechanistic basis of life history evolution in anuran amphibians: thyroid gland development in the direct-developing frog, Eleutherodactylus coqui.
1998,
Pubmed Kanamori,
The regulation of thyroid hormone receptor beta genes by thyroid hormone in Xenopus laevis.
1992,
Pubmed
,
Xenbase Kawahara,
Developmental and regional expression of thyroid hormone receptor genes during Xenopus metamorphosis.
1991,
Pubmed
,
Xenbase Klymkowsky,
Whole-mount staining of Xenopus and other vertebrates.
1991,
Pubmed
,
Xenbase Lynch,
Growth and metamorphosis of the rectus abdominis muscle in Rana pipiens.
1984,
Pubmed LYNN,
The role of the thyroid gland in direct development in the anuran, Eleutherodactylus martinicensis.
1955,
Pubmed Murphy,
Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression.
1990,
Pubmed Schneider,
Rana catesbeiana tadpole red blood cells express an alpha, but not a beta, c-erbA gene.
1993,
Pubmed TAYLOR,
Stages in the normal development of Rana pipiens larvae.
1946,
Pubmed Weber,
Patterns of thyroxine and triiodothyronine in serum and follicle-bound oocytes of the tilapia, Oreochromis mossambicus, during oogenesis.
1992,
Pubmed Weber,
Changes in whole-body thyroxine and triiodothyronine concentrations and total content during early development and metamorphosis of the toad Bufo marinus.
1994,
Pubmed Yaoita,
A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis.
1990,
Pubmed
,
Xenbase
