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Glomeruli in the vertebrate olfactory bulb (OB) appear as anatomically discrete modules receiving direct input from the olfactory epithelium (OE) via axons of olfactory receptor neurons (ORNs). The response profiles with respect to amino acids (AAs) of a large number of ORNs in larval Xenopus laevis have been recently determined and analysed. Here we report on Ca(2+) imaging experiments in a nose-brain preparation of the same species at the same developmental stages. We recorded responses to AAs of glomeruli in the OB and determined the response profiles to AAs of individual glomeruli. We describe the general features of AA-responsive glomeruli and compare their response profiles to AAs with those of ORNs obtained in our previous study. A large number of past studies have focused either on odorant responses in the OE or on odorant-induced responses in the OB. However, a thorough comparison of odorant-induced responses of both stages, ORNs and glomeruli of the same species is as yet lacking. The glomerular response profiles reported herein markedly differ from the previously obtained response profiles of ORNs in that glomeruli clearly have narrower selectivity profiles than ORNs. We discuss possible explanations for the different selectivity profiles of glomeruli and ORNs in the context of the development of the olfactory map.
Abrahamse,
Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A.
2001, Pubmed
Abrahamse,
Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A.
2001,
Pubmed Aungst,
Centre-surround inhibition among olfactory bulb glomeruli.
2003,
Pubmed Becerra,
Primary olfactory fibres project to the ventral telencephalon and preoptic region in trout (Salmo trutta): a developmental immunocytochemical study.
1994,
Pubmed Berkowicz,
Evidence for glutamate as the olfactory receptor cell neurotransmitter.
1994,
Pubmed Caprio,
Electrophysiological evidence for acidic, basic, and neutral amino acid olfactory receptor sites in the catfish.
1984,
Pubmed Cleland,
Computation in the olfactory system.
2005,
Pubmed Czesnik,
Neuronal representation of odourants in the olfactory bulb of Xenopus laevis tadpoles.
2003,
Pubmed
,
Xenbase Czesnik,
ATP activates both receptor and sustentacular supporting cells in the olfactory epithelium of Xenopus laevis tadpoles.
2006,
Pubmed
,
Xenbase Duchamp-Viret,
Amplifying role of convergence in olfactory system a comparative study of receptor cell and second-order neuron sensitivities.
1989,
Pubmed Duchamp-Viret,
Odor response properties of rat olfactory receptor neurons.
1999,
Pubmed Edwards,
A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system.
1989,
Pubmed Ennis,
Olfactory nerve stimulation activates rat mitral cells via NMDA and non-NMDA receptors in vitro.
1996,
Pubmed Feinstein,
Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor.
2004,
Pubmed Feinstein,
A contextual model for axonal sorting into glomeruli in the mouse olfactory system.
2004,
Pubmed Fried,
Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli.
2002,
Pubmed Friedrich,
Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging.
1997,
Pubmed Friedrich,
Chemotopic, combinatorial, and noncombinatorial odorant representations in the olfactory bulb revealed using a voltage-sensitive axon tracer.
1998,
Pubmed Gekeler,
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.
1995,
Pubmed Gesteland,
Development of olfactory receptor neuron selectivity in the rat fetus.
1982,
Pubmed Graziadei,
Regeneration of olfactory axons and synapse formation in the forebrain after bulbectomy in neonatal mice.
1978,
Pubmed Hálasz,
Terminal arborizations of olfactory nerve fibers in the glomeruli of the olfactory bulb.
1993,
Pubmed Hansen,
Correlation between olfactory receptor cell type and function in the channel catfish.
2003,
Pubmed Hara,
Topographic bulbar projections and dual neural pathways of the primary olfactory neurons in salmonid fishes.
1998,
Pubmed Hildebrand,
Mechanisms of olfactory discrimination: converging evidence for common principles across phyla.
1997,
Pubmed Hofmann,
The extrabulbar olfactory pathway: primary olfactory fibers bypassing the olfactory bulb in bony fishes?
1995,
Pubmed Hofmann,
Peripheral origin of olfactory nerve fibers by-passing the olfactory bulb in Xenopus laevis.
1992,
Pubmed
,
Xenbase Honkanen,
An immunocytochemical study of the olfactory projections in the three-spined stickleback, Gasterosteus aculeatus, L.
1990,
Pubmed Howell,
Acid-base balance in cold-blooded vertebrates as a function of body temperature.
1970,
Pubmed Imai,
Odorant receptor-derived cAMP signals direct axonal targeting.
2006,
Pubmed Johnson,
Multidimensional chemotopic responses to n-aliphatic acid odorants in the rat olfactory bulb.
1999,
Pubmed Kang,
In vivo responses of single olfactory receptor neurons in the channel catfish, Ictalurus punctatus.
1995,
Pubmed Kasowski,
Compartmental organization of the olfactory bulb glomerulus.
1999,
Pubmed Kitamura,
Olfactory responses of several species of teleost to F-prostaglandins.
1994,
Pubmed Kosaka,
Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb--II. Prominent differences in the intraglomerular dendritic arborization and their relationship to olfactory nerve terminals.
1997,
Pubmed Lancet,
Mapping of odor-related neuronal activity in the olfactory bulb by high-resolution 2-deoxyglucose autoradiography.
1982,
Pubmed Lledo,
Information processing in the mammalian olfactory system.
2005,
Pubmed Ma,
Functional mosaic organization of mouse olfactory receptor neurons.
2000,
Pubmed Manzini,
Odorant responses of Xenopus laevis tadpole olfactory neurons: a comparison between preparations.
2002,
Pubmed
,
Xenbase Manzini,
Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles.
2003,
Pubmed
,
Xenbase Manzini,
cAMP-independent responses of olfactory neurons in Xenopus laevis tadpoles and their projection onto olfactory bulb neurons.
2002,
Pubmed
,
Xenbase Manzini,
Classes and narrowing selectivity of olfactory receptor neurons of Xenopus laevis tadpoles.
2004,
Pubmed
,
Xenbase Manzini,
cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles.
2003,
Pubmed
,
Xenbase Meister,
Tuning and topography in an odor map on the rat olfactory bulb.
2001,
Pubmed Miyasaka,
Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system.
2005,
Pubmed Mombaerts,
Seven-transmembrane proteins as odorant and chemosensory receptors.
1999,
Pubmed Mombaerts,
Visualizing an olfactory sensory map.
1996,
Pubmed Mombaerts,
Targeting olfaction.
1996,
Pubmed Nezlin,
Structure of the olfactory bulb in tadpoles of Xenopus laevis.
2000,
Pubmed
,
Xenbase Nezlin,
Individual olfactory sensory neurons project into more than one glomerulus in Xenopus laevis tadpole olfactory bulb.
2005,
Pubmed
,
Xenbase Nezlin,
Organization of glomeruli in the main olfactory bulb of Xenopus laevis tadpoles.
2003,
Pubmed
,
Xenbase Nikonov,
Electrophysiological evidence for a chemotopy of biologically relevant odors in the olfactory bulb of the channel catfish.
2001,
Pubmed Pinelli,
Extrabulbar olfactory system and nervus terminalis FMRFamide immunoreactive components in Xenopus laevis ontogenesis.
2004,
Pubmed
,
Xenbase Potter,
Structure and emergence of specific olfactory glomeruli in the mouse.
2001,
Pubmed Ressler,
A zonal organization of odorant receptor gene expression in the olfactory epithelium.
1993,
Pubmed Ressler,
Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.
1994,
Pubmed Rössler,
Development of a glia-rich axon-sorting zone in the olfactory pathway of the moth Manduca sexta.
1999,
Pubmed Rubin,
Optical imaging of odorant representations in the mammalian olfactory bulb.
1999,
Pubmed Sato,
Whole-cell response characteristics of ciliated and microvillous olfactory receptor neurons to amino acids, pheromone candidates and urine in rainbow trout.
2001,
Pubmed Schild,
Cascades of response vectors of olfactory receptor neurons in Xenopus laevis tadpoles.
2004,
Pubmed
,
Xenbase Schwarzenbacher,
Odorant receptor proteins in olfactory axons and in cells of the cribriform mesenchyme may contribute to fasciculation and sorting of nerve fibers.
2006,
Pubmed Serizawa,
A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.
2006,
Pubmed Shipley,
Functional organization of olfactory system.
1996,
Pubmed Sicard,
Receptor cell responses to odorants: similarities and differences among odorants.
1984,
Pubmed Sorensen,
F prostaglandins function as potent olfactory stimulants that comprise the postovulatory female sex pheromone in goldfish.
1988,
Pubmed St John,
Sorting and convergence of primary olfactory axons are independent of the olfactory bulb.
2003,
Pubmed Strotmann,
Local permutations in the glomerular array of the mouse olfactory bulb.
2000,
Pubmed Strotmann,
Olfactory receptor proteins in axonal processes of chemosensory neurons.
2004,
Pubmed Strotmann,
Rostro-caudal patterning of receptor-expressing olfactory neurones in the rat nasal cavity.
1994,
Pubmed Szabo,
[Extra-bulbar primary olfactory projection in teleost fishes].
1991,
Pubmed Treloar,
Glomerular formation in the developing rat olfactory bulb.
1999,
Pubmed Uchida,
Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features.
2000,
Pubmed Valverde,
Formation of an olfactory glomerulus: morphological aspects of development and organization.
1992,
Pubmed Vassar,
Topographic organization of sensory projections to the olfactory bulb.
1994,
Pubmed Vassar,
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium.
1993,
Pubmed Vogler,
Inhibitory and excitatory responses of olfactory receptor neurons of xenopus laevis tadpoles to stimulation with amino acids.
1999,
Pubmed
,
Xenbase Wachowiak,
Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging.
2004,
Pubmed Wang,
Odorant receptors govern the formation of a precise topographic map.
1998,
Pubmed Zheng,
Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit.
2000,
Pubmed
