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Allopolyploid species form through the fusion of two differentiated genomes and, in the earliest stages of their evolution, essentially all genes in the nucleus are duplicated. Because unique mutations occur in each ancestor prior to allopolyploidization, duplicate genes in these species potentially are not interchangeable, and this could influence their genetic fates. This study explores evolution and expression of a simple duplicated complex--a heterodimer between RAG1 and RAG2 proteins in clawed frogs (Xenopus). Results demonstrate that copies of RAG1 degenerated in different polyploid species in a phylogenetically biased fashion, predominately in only one lineage of closely related paralogs. Surprisingly, as a result of an early deletion of one RAG2 paralog, it appears that in many species RAG1/RAG2 heterodimers are composed of proteins that were encoded by unlinked paralogs. If the tetraploid ancestor of extant species of Xenopus arose through allopolyploidization and if recombination between paralogs was rare, then the genes that encode functional RAG1 and RAG2 proteins in many polyploid species were each ultimately inherited from different diploid progenitors. These observations are consistent with the notion that ancestry can influence the fate of duplicate genes millions of years after duplication, and they uncover a dimension of natural selection in allopolyploid genomes that is distinct from other genetic phenomena associated with polyploidization or segmental duplication.
Adams,
Genes duplicated by polyploidy show unequal contributions to the transcriptome and organ-specific reciprocal silencing.
2003, Pubmed
Adams,
Genes duplicated by polyploidy show unequal contributions to the transcriptome and organ-specific reciprocal silencing.
2003,
Pubmed Adams,
Polyploidy and genome evolution in plants.
2005,
Pubmed Adams,
Organ-specific silencing of duplicated genes in a newly synthesized cotton allotetraploid.
2004,
Pubmed Chain,
Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis.
2006,
Pubmed
,
Xenbase Comai,
Genetic and epigenetic interactions in allopolyploid plants.
2000,
Pubmed Cronn,
Duplicated genes evolve independently after polyploid formation in cotton.
1999,
Pubmed Davenport,
DEGENERATION, ALBINISM AND INBREEDING.
1908,
Pubmed Evans,
Evolution of RAG-1 in polyploid clawed frogs.
2005,
Pubmed
,
Xenbase Evans,
A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution.
2004,
Pubmed
,
Xenbase Force,
Preservation of duplicate genes by complementary, degenerative mutations.
1999,
Pubmed Forsdyke,
The heat-shock response and the molecular basis of genetic dominance.
1994,
Pubmed Gibbs,
Sister-scanning: a Monte Carlo procedure for assessing signals in recombinant sequences.
2000,
Pubmed Goldman,
Likelihood-based tests of topologies in phylogenetics.
2000,
Pubmed Greenhalgh,
Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopus laevis.
1993,
Pubmed
,
Xenbase Gu,
Evolution of duplicate genes versus genetic robustness against null mutations.
2003,
Pubmed Hughes,
Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.
1993,
Pubmed
,
Xenbase Jackson,
Parasite infectivity to hybridising host species: a link between hybrid resistance and allopolyploid speciation?
2003,
Pubmed
,
Xenbase Jiang,
Multilocus interactions restrict gene introgression in interspecific populations of polyploid Gossypium (cotton).
2000,
Pubmed Kacser,
The molecular basis of dominance.
1981,
Pubmed Kapitonov,
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons.
2005,
Pubmed Lee,
Protein-coding genes are epigenetically regulated in Arabidopsis polyploids.
2001,
Pubmed Liu,
Polyploid formation in cotton is not accompanied by rapid genomic changes.
2001,
Pubmed Liu,
Epigenetic phenomena and the evolution of plant allopolyploids.
2003,
Pubmed Lynch,
The probability of preservation of a newly arisen gene duplicate.
2001,
Pubmed Lynch,
The probability of duplicate gene preservation by subfunctionalization.
2000,
Pubmed Madlung,
Remodeling of DNA methylation and phenotypic and transcriptional changes in synthetic Arabidopsis allotetraploids.
2002,
Pubmed Martin,
RDP: detection of recombination amongst aligned sequences.
2000,
Pubmed Moscone,
The use of combined FISH/GISH in conjunction with DAPI counterstaining to identify chromosomes containing transgene inserts in amphidiploid tobacco.
1996,
Pubmed Nylander,
Bayesian phylogenetic analysis of combined data.
2004,
Pubmed Orr,
A test of Fisher's theory of dominance.
1991,
Pubmed Ozkan,
Allopolyploidy-induced rapid genome evolution in the wheat (Aegilops-Triticum) group.
2001,
Pubmed Padidam,
Possible emergence of new geminiviruses by frequent recombination.
1999,
Pubmed Papp,
Dosage sensitivity and the evolution of gene families in yeast.
2003,
Pubmed Posada,
Evaluation of methods for detecting recombination from DNA sequences: empirical data.
2002,
Pubmed Posada,
Evaluation of methods for detecting recombination from DNA sequences: computer simulations.
2001,
Pubmed Rambaut,
Seq-Gen: an application for the Monte Carlo simulation of DNA sequence evolution along phylogenetic trees.
1997,
Pubmed Ramsden,
Conservation of sequence in recombination signal sequence spacers.
1994,
Pubmed Sadofsky,
Expression and V(D)J recombination activity of mutated RAG-1 proteins.
1993,
Pubmed Sakano,
Sequences at the somatic recombination sites of immunoglobulin light-chain genes.
1979,
Pubmed Salminen,
Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning.
1995,
Pubmed Shaked,
Sequence elimination and cytosine methylation are rapid and reproducible responses of the genome to wide hybridization and allopolyploidy in wheat.
2001,
Pubmed Skalická,
Preferential elimination of repeated DNA sequences from the paternal, Nicotiana tomentosiformis genome donor of a synthetic, allotetraploid tobacco.
2005,
Pubmed Smith,
Analyzing the mosaic structure of genes.
1992,
Pubmed Veitia,
Exploring the etiology of haploinsufficiency.
2002,
Pubmed Volkov,
Elimination and rearrangement of parental rDNA in the allotetraploid Nicotiana tabacum.
1999,
Pubmed Wendel,
Bidirectional interlocus concerted evolution following allopolyploid speciation in cotton (Gossypium).
1995,
Pubmed Yang,
PAML: a program package for phylogenetic analysis by maximum likelihood.
1997,
Pubmed
