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The evolutionarily conserved RNA-binding protein, Musashi, regulates neural stem cell self-renewal. Musashi expression is also indicative of stem cell populations in breast and intestinal tissues and is linked to cell overproliferation in cancers of these tissues. Musashi has been primarily implicated as a repressor of target mRNAs in stem cell populations. However, little is known about the mechanism by which Musashi exerts mRNA translational control or how Musashi function is regulated. Recent findings in oocytes of the frog, Xenopus, indicate an unexpected role for Musashi as an activator of a number of maternal mRNAs during meiotic cell cycle progression. Given the importance of Musashi function in stem cell biology and the implications of aberrant Musashi expression in cancer, it is critical that we understand the molecular processes that regulate Musashi function.
Battelli,
The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1.
2006, Pubmed
Battelli,
The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1.
2006,
Pubmed Charlesworth,
Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation.
2006,
Pubmed
,
Xenbase Clarke,
A putative human breast stem cell population is enriched for steroid receptor-positive cells.
2005,
Pubmed Clarke,
Regulation of human breast epithelial stem cells.
2003,
Pubmed Cuadrado,
Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1.
2002,
Pubmed Erhardt,
Ectopic p21(WAF1) expression induces differentiation-specific cell cycle changes in PC12 cells characteristic of nerve growth factor treatment.
1998,
Pubmed Hemmati,
Cancerous stem cells can arise from pediatric brain tumors.
2003,
Pubmed Hitoshi,
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
2002,
Pubmed Hughes,
Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation.
2000,
Pubmed Imai,
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.
2001,
Pubmed Kageyama,
Roles of bHLH genes in neural stem cell differentiation.
2005,
Pubmed Kayahara,
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine.
2003,
Pubmed Kurihara,
Structural properties and RNA-binding activities of two RNA recognition motifs of a mouse neural RNA-binding protein, mouse-Musashi-1.
1997,
Pubmed Nakamura,
Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development.
1994,
Pubmed Okano,
Function of RNA-binding protein Musashi-1 in stem cells.
2005,
Pubmed Okano,
Musashi: a translational regulator of cell fate.
2002,
Pubmed Ratti,
A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA.
2006,
Pubmed Sakakibara,
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.
2002,
Pubmed Toda,
Expression of the neural RNA-binding protein Musashi1 in human gliomas.
2001,
Pubmed Yan,
NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1.
1995,
Pubmed Yokota,
Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization.
2004,
Pubmed Yoon,
Notch signaling in the mammalian central nervous system: insights from mouse mutants.
2005,
Pubmed
