Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Anat Rec (Hoboken)
2008 May 01;2915:475-87. doi: 10.1002/ar.20670.
Show Gene links
Show Anatomy links
Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms.
Vasquez SX, Hansen MS, Bahadur AN, Hockin MF, Kindlmann GL, Nevell L, Wu IQ, Grunwald DJ, Weinstein DM, Jones GM, Johnson CR, Vandeberg JL, Capecchi MR, Keller C.
???displayArticle.abstract???
Forward and reverse genetics now allow researchers to understand embryonic and postnatal gene function in a broad range of species. Although some genetic mutations cause obvious morphological change, other mutations can be more subtle and, without adequate observation and quantification, might be overlooked. For the increasing number of genetic model organisms examined by the growing field of phenomics, standardized but sensitive methods for quantitative analysis need to be incorporated into routine practice to effectively acquire and analyze ever-increasing quantities of phenotypic data. In this study, we present platform-independent parameters for the use of microscopic x-ray computed tomography (microCT) for phenotyping species-specific skeletal morphology of a variety of different genetic model organisms. We show that microCT is suitable for phenotypic characterization for prenatal and postnatal specimens across multiple species.
Abzhanov,
Bmp4 and morphological variation of beaks in Darwin's finches.
2004, Pubmed
Abzhanov,
Bmp4 and morphological variation of beaks in Darwin's finches.
2004,
Pubmed Attwood,
Microscopy: nanotomography comes of age.
2006,
Pubmed Austin,
The knockout mouse project.
2004,
Pubmed Belov,
Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system.
2007,
Pubmed Beltran,
Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus).
2007,
Pubmed Bons,
Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?
2006,
Pubmed Brown,
Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.
2006,
Pubmed Brugmann,
Looking different: understanding diversity in facial form.
2006,
Pubmed Brunet-Rossinni,
Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals.
2004,
Pubmed Cayetanot,
Shortened seasonal photoperiodic cycles accelerate aging of the diurnal and circadian locomotor activity rhythms in a primate.
2005,
Pubmed Chan,
Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica.
2002,
Pubmed Dawid,
Developmental biology of zebrafish.
2004,
Pubmed Driever,
A genetic screen for mutations affecting embryogenesis in zebrafish.
1996,
Pubmed Ek,
Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica).
2006,
Pubmed Frey,
Electron tomography of membrane-bound cellular organelles.
2006,
Pubmed Freyer,
Placental function in two distantly related marsupials.
2007,
Pubmed Gallwitz,
Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution.
2006,
Pubmed Geisler,
Large-scale mapping of mutations affecting zebrafish development.
2007,
Pubmed Génin,
Melatonin and methimazole mimic short-day-induced fattening in gray mouse lemurs.
2003,
Pubmed Génin,
Daily hypothermia in captive grey mouse lemurs (Microcebus murinus): effects of photoperiod and food restriction.
2003,
Pubmed Goodstadt,
An analysis of the gene complement of a marsupial, Monodelphis domestica: evolution of lineage-specific genes and giant chromosomes.
2007,
Pubmed Holzer,
Three-dimensional analysis of porous BaTiO3 ceramics using FIB nanotomography.
2004,
Pubmed Hsu,
The zebrafish model: use in studying cellular mechanisms for a spectrum of clinical disease entities.
2007,
Pubmed Huang,
A genetic and cytogenetic map for the duck (Anas platyrhynchos).
2006,
Pubmed Johnson,
Virtual histology of transgenic mouse embryos for high-throughput phenotyping.
2006,
Pubmed Kindlmann,
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.
2005,
Pubmed Kitchener,
Primary sensory afferent innervation of the developing superficial dorsal horn in the South American opossum Monodelphis domestica.
2006,
Pubmed Kohl,
Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease.
2007,
Pubmed KUEHNEL,
[Morphological and experimental studies on the allantois of chickens].
1961,
Pubmed KUROSE,
The developmental and morphological findings of the anterior chamber angle in chickens. Preliminary results.
1961,
Pubmed Landstrom,
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.
2007,
Pubmed Larabell,
X-ray tomography generates 3-D reconstructions of the yeast, saccharomyces cerevisiae, at 60-nm resolution.
2004,
Pubmed Lehoczky,
Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.
2004,
Pubmed Matera,
A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3.
2007,
Pubmed Mikkelsen,
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.
2007,
Pubmed Movérare,
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice.
2003,
Pubmed Nahrendorf,
High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT.
2007,
Pubmed Nieman,
Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography.
2006,
Pubmed Ogino,
High-throughput transgenesis in Xenopus using I-SceI meganuclease.
2006,
Pubmed
,
Xenbase Ohuchi,
Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4.
1998,
Pubmed Pantin-Jackwood,
Pathobiology of Asian highly pathogenic avian influenza H5N1 virus infections in ducks.
2007,
Pubmed Paulus,
A review of high-resolution X-ray computed tomography and other imaging modalities for small animal research.
2001,
Pubmed Perlyn,
The craniofacial phenotype of the Crouzon mouse: analysis of a model for syndromic craniosynostosis using three-dimensional MicroCT.
2006,
Pubmed Picq,
Aging affects executive functions and memory in mouse lemur primates.
2007,
Pubmed Podlutsky,
A new field record for bat longevity.
2005,
Pubmed Puchtler,
On the history and mechanism of alizarin and alizarin red S stains for calcium.
1969,
Pubmed Sabsovich,
Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan.
2008,
Pubmed Saito,
Level-specific role of paraxial mesoderm in regulation of Tbx5/Tbx4 expression and limb initiation.
2006,
Pubmed Sánchez-Villagra,
Ontogenesis of the scapula in marsupial mammals, with special emphasis on perinatal stages of didelphids and remarks on the origin of the therian scapula.
2003,
Pubmed Scott,
Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions.
1965,
Pubmed Shahnazari,
Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens.
2006,
Pubmed Shanmugarajan,
Transgenic mice with OIP-1/hSca overexpression targeted to the osteoclast lineage develop an osteopetrosis bone phenotype.
2007,
Pubmed Silha,
Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice.
2003,
Pubmed Tsukumo,
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
2007,
Pubmed Turner,
Congenic mice reveal sex-specific genetic regulation of femoral structure and strength.
2003,
Pubmed Van Borm,
A universal avian endogenous real-time reverse transcriptase-polymerase chain reaction control and its application to avian influenza diagnosis and quantification.
2007,
Pubmed Vigh,
The development of the paraventricular organ in the white Leghorn chicken.
1968,
Pubmed Wallis,
A physical map of the chicken genome.
2004,
Pubmed Wang,
Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis.
2008,
Pubmed Whitesides,
Nanoscience, nanotechnology, and chemistry.
2005,
Pubmed Wu,
Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution.
2006,
Pubmed Wu,
Molecular shaping of the beak.
2004,
Pubmed Yamamoto,
Severe nonpurulent encephalitis with mortality and feather lesions in call ducks (Anas platyrhyncha var. domestica) inoculated intravenously with H5N1 highly pathogenic avian influenza virus.
2007,
Pubmed Zhou,
Genome-wide linkage analysis to identify chromosomal regions affecting phenotypic traits in the chicken. III. Skeletal integrity.
2007,
Pubmed
