Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Neuron
2008 Jun 26;586:859-70. doi: 10.1016/j.neuron.2008.04.016.
Show Gene links
Show Anatomy links
Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.
Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SA.
???displayArticle.abstract???
K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy. Full-length K(2P)2.1 and an isoform lacking the first 56 residues of the intracellular N terminus (K(2P)2.1Delta1-56) are produced differentially in a regional and developmental manner in the rat central nervous system, the latter passing sodium under physiological conditions leading to membrane depolarization. Control of ion selectivity via ATI is proposed to be a natural, epigenetic mechanism for spatial and temporal regulation of neuronal excitability.
Bockenhauer,
KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.
2001, Pubmed,
Xenbase
Bockenhauer,
KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.
2001,
Pubmed
,
Xenbase Cai,
Alteration of protein subcellular location and domain formation by alternative translational initiation.
2006,
Pubmed Doyle,
The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
1998,
Pubmed Duprat,
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.
2000,
Pubmed Fernandez,
Inactivation of Kv3.3 potassium channels in heterologous expression systems.
2003,
Pubmed Fink,
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
1996,
Pubmed
,
Xenbase Galy,
Cell transformation results in the loss of the density-dependent translational regulation of the expression of fibroblast growth factor 2 isoforms.
1999,
Pubmed Goldstein,
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.
2005,
Pubmed Goldstein,
Potassium leak channels and the KCNK family of two-P-domain subunits.
2001,
Pubmed Goldstein,
ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae.
1996,
Pubmed
,
Xenbase Hann,
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
1988,
Pubmed
,
Xenbase Heinemann,
Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue.
1986,
Pubmed Heurteaux,
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype.
2006,
Pubmed Honoré,
Desensitization of mechano-gated K2P channels.
2006,
Pubmed Ilan,
Kcnkø: single, cloned potassium leak channels are multi-ion pores.
2001,
Pubmed
,
Xenbase Kennard,
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine.
2005,
Pubmed Ketchum,
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.
1995,
Pubmed
,
Xenbase Kevil,
Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.
1995,
Pubmed Kindler,
Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
1999,
Pubmed
,
Xenbase Kiss,
Contribution of the selectivity filter to inactivation in potassium channels.
1999,
Pubmed Kofuji,
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells.
1996,
Pubmed
,
Xenbase Korn,
Permeation selectivity by competition in a delayed rectifier potassium channel.
1995,
Pubmed Kozak,
An analysis of vertebrate mRNA sequences: intimations of translational control.
1991,
Pubmed Kozak,
Initiation of translation in prokaryotes and eukaryotes.
1999,
Pubmed Lopes,
Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.
2001,
Pubmed
,
Xenbase Lu,
The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.
2007,
Pubmed
,
Xenbase Lu,
Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.
2005,
Pubmed Macri,
Separable gating mechanisms in a Mammalian pacemaker channel.
2002,
Pubmed Maingret,
Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.
2000,
Pubmed Marks,
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
2005,
Pubmed Mellentin,
lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif.
1989,
Pubmed Neher,
Correction for liquid junction potentials in patch clamp experiments.
1992,
Pubmed Neyton,
Potassium blocks barium permeation through a calcium-activated potassium channel.
1988,
Pubmed Neyton,
Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel.
1988,
Pubmed Noskov,
Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.
2004,
Pubmed Patel,
Inhalational anesthetics activate two-pore-domain background K+ channels.
1999,
Pubmed Plant,
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.
2006,
Pubmed Rhen,
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.
2005,
Pubmed Sánchez-Sánchez,
Attenuation of disease phenotype through alternative translation initiation in low-penetrance retinoblastoma.
2007,
Pubmed Sesti,
Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.
1998,
Pubmed
,
Xenbase Shi,
Atomic structure of a Na+- and K+-conducting channel.
2006,
Pubmed Shin,
Sodium permeability of a cloned small-conductance calcium-activated potassium channel.
2005,
Pubmed
,
Xenbase Starkus,
Ion conduction through C-type inactivated Shaker channels.
1997,
Pubmed
,
Xenbase Touriol,
Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons.
2003,
Pubmed Vagner,
Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells.
1996,
Pubmed Wang,
Regulation of transient Na+ conductance by intra- and extracellular K+ in the human delayed rectifier K+ channel Kv1.5.
2000,
Pubmed Wollnik,
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.
1997,
Pubmed Yang,
Thrilling moment of an inhibitory channel.
2008,
Pubmed Zilberberg,
KCNKØ: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore.
2001,
Pubmed
,
Xenbase
