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In early development of animals, hedgehog (Hh) genes function as morphogen in the axis determination and the organ formation. In Xenopus, three hedgehog genes, sonic (shh), banded (bhh), and cephalic (chh), were identified and might organize various tissues and organs in embryogenesis. Here, we report the spatial and temporal regulation of Xchh which is expressed in endoderm cells differentiating to digestive organs. Xchh expression in endoderm was inhibited by ectopic expression of the dominant-negative activin receptor, tAR. Moreover, a maternally inherited transcription factor VegT and its downstream regulators activated Xchh expression. These indicates that Xchh is regulated by the factor involved in the cascade originated from VegT via activin/nodal signals. Using the Sox17alpha-VP16-GR construct, we showed that Xchh expression might be induced directly by transcription factor Sox17.
Afouda,
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
2005, Pubmed,
Xenbase
Afouda,
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
2005,
Pubmed
,
Xenbase Amaya,
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
1991,
Pubmed
,
Xenbase Asashima,
The vegetalizing factor from chicken embryos: its EDF (activin A)-like activity.
1991,
Pubmed Bartkowski,
Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis.
1993,
Pubmed
,
Xenbase Casey,
Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development.
1999,
Pubmed
,
Xenbase Clements,
Mode of action of VegT in mesoderm and endoderm formation.
1999,
Pubmed
,
Xenbase Clements,
Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm development.
2003,
Pubmed
,
Xenbase Clements,
VegT induces endoderm by a self-limiting mechanism and by changing the competence of cells to respond to TGF-beta signals.
2003,
Pubmed
,
Xenbase Demartis,
Cloning and developmental expression of LFB3/HNF1 beta transcription factor in Xenopus laevis.
1994,
Pubmed
,
Xenbase Dohrmann,
Expression of activin mRNA during early development in Xenopus laevis.
1993,
Pubmed
,
Xenbase Echelard,
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
1993,
Pubmed Ecochard,
A novel Xenopus mix-like gene milk involved in the control of the endomesodermal fates.
1998,
Pubmed
,
Xenbase Ekker,
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.
1995,
Pubmed
,
Xenbase Engleka,
VegT activation of Sox17 at the midblastula transition alters the response to nodal signals in the vegetal endoderm domain.
2001,
Pubmed
,
Xenbase Fan,
Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog.
1994,
Pubmed Hammerschmidt,
The world according to hedgehog.
1997,
Pubmed Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase Hemmati-Brivanlou,
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.
1992,
Pubmed
,
Xenbase Henry,
Mixer, a homeobox gene required for endoderm development.
1998,
Pubmed
,
Xenbase Hudson,
Xsox17alpha and -beta mediate endoderm formation in Xenopus.
1997,
Pubmed
,
Xenbase Ito,
In synergy with noggin and follistatin, Xenopus nodal-related gene induces sonic hedgehog on notochord and floor plate.
2001,
Pubmed
,
Xenbase Jiang,
The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis.
1996,
Pubmed
,
Xenbase Jones,
The possible role of mesodermal growth factors in the formation of endoderm inXenopus laevis.
1993,
Pubmed
,
Xenbase Joseph,
Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.
1997,
Pubmed
,
Xenbase Kelley,
GATA-4 is a novel transcription factor expressed in endocardium of the developing heart.
1993,
Pubmed
,
Xenbase Krauss,
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos.
1993,
Pubmed Lemaire,
A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone.
1998,
Pubmed
,
Xenbase Nüsslein-Volhard,
Mutations affecting segment number and polarity in Drosophila.
1980,
Pubmed Peng,
Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols.
1991,
Pubmed
,
Xenbase Roelink,
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord.
1994,
Pubmed
,
Xenbase Rosa,
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos.
1989,
Pubmed
,
Xenbase Sasai,
Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps.
1996,
Pubmed
,
Xenbase Shi,
Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis.
1994,
Pubmed
,
Xenbase Sinner,
Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes.
2004,
Pubmed
,
Xenbase Sun,
derrière: a TGF-beta family member required for posterior development in Xenopus.
1999,
Pubmed
,
Xenbase Suzuki,
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
1994,
Pubmed
,
Xenbase Tada,
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm.
1998,
Pubmed
,
Xenbase Takahashi,
Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center.
2000,
Pubmed
,
Xenbase Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase Vize,
DNA sequences mediating the transcriptional response of the Mix.2 homeobox gene to mesoderm induction.
1996,
Pubmed
,
Xenbase Weber,
A role for GATA5 in Xenopus endoderm specification.
2000,
Pubmed
,
Xenbase Wright,
XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm.
1989,
Pubmed
,
Xenbase Xanthos,
Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis.
2001,
Pubmed
,
Xenbase Yisraeli,
The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes.
1988,
Pubmed
,
Xenbase Zhang,
SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus.
2005,
Pubmed
,
Xenbase Zhang,
The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation.
2003,
Pubmed
,
Xenbase Zhang,
SOX7 and SOX18 are essential for cardiogenesis in Xenopus.
2005,
Pubmed
,
Xenbase
