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Transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine phosphorylation of STAT3 induced by TAK1-NLK cascade is essential fo TGF-beta-mediated mesoderm induction in Xenopus embryo. Depletion of TAK1, NLK, or STAT3 blocks TGF-beta-mediated mesoderm induction. Coexpression of NLK and STAT3 induces mesoderm by a mechanism that requires serine phosphorylation of STAT3. Activin activates NLK, which in turn directly phosphorylates STAT3. Moreover, depletion of either TAK1 or NLK inhibits endogenous serine phosphorylation of STAT3. These results provide the first evidence that TAK1-NLK-STAT3 cascade participates in TGF-beta-mediated mesoderm induction.
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Agius,
Endodermal Nodal-related signals and mesoderm induction in Xenopus.
2000, Pubmed,
Xenbase
Agius,
Endodermal Nodal-related signals and mesoderm induction in Xenopus.
2000,
Pubmed
,
Xenbase Amaya,
FGF signalling in the early specification of mesoderm in Xenopus.
1993,
Pubmed
,
Xenbase Attisano,
Mads and Smads in TGF beta signalling.
1998,
Pubmed
,
Xenbase Bromberg,
Stat3 as an oncogene.
1999,
Pubmed Candia,
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.
1997,
Pubmed
,
Xenbase Darnell,
STATs and gene regulation.
1997,
Pubmed Decker,
Serine phosphorylation of STATs.
2000,
Pubmed Derynck,
Smads: transcriptional activators of TGF-beta responses.
1998,
Pubmed Heldin,
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
1997,
Pubmed Hirano,
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
2000,
Pubmed Hyodo-Miura,
Involvement of NLK and Sox11 in neural induction in Xenopus development.
2002,
Pubmed
,
Xenbase Ishitani,
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.
2003,
Pubmed Ishitani,
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
1999,
Pubmed
,
Xenbase Kimelman,
Mesoderm induction: a postmodern view.
1998,
Pubmed
,
Xenbase Massagué,
How cells read TGF-beta signals.
2000,
Pubmed Meneghini,
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
1999,
Pubmed Nakashima,
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
1999,
Pubmed Nishinakamura,
Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4.
1999,
Pubmed
,
Xenbase O'Shea,
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
2002,
Pubmed Shibuya,
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
1998,
Pubmed
,
Xenbase Shibuya,
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
1996,
Pubmed Smith,
Xwnt11 and the regulation of gastrulation in Xenopus.
2000,
Pubmed
,
Xenbase Smith,
Mesoderm-inducing factors and mesodermal patterning.
1995,
Pubmed
,
Xenbase Symes,
Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin.
1994,
Pubmed
,
Xenbase Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase Wallingford,
Convergent extension: the molecular control of polarized cell movement during embryonic development.
2002,
Pubmed
,
Xenbase Whitman,
Smads and early developmental signaling by the TGFbeta superfamily.
1998,
Pubmed Yamada,
Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein.
2003,
Pubmed
,
Xenbase Yamaguchi,
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
1995,
Pubmed
