Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-39816
Trends Cell Biol 2008 Nov 01;1811:517-20. doi: 10.1016/j.tcb.2008.08.004.
Show Gene links Show Anatomy links

Dishevelled links basal body docking and orientation in ciliated epithelial cells.

Vladar EK, Axelrod JD.


???displayArticle.abstract???
Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.

???displayArticle.pubmedLink??? 18819800
???displayArticle.pmcLink??? PMC3989925
???displayArticle.link??? Trends Cell Biol
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: dvl2

References [+] :
Boisvieux-Ulrich, Determination of ciliary polarity precedes differentiation in the epithelial cells of quail oviduct. 1991, Pubmed