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The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK.
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Potassium channels activated by intracellular Na(+) ions (K(Na)) play several distinct roles in regulating the firing patterns of neurons, and, at the single channel level, their properties are quite diverse. Two known genes, Slick and Slack, encode K(Na) channels. We have now found that Slick and Slack subunits coassemble to form heteromeric channels that differ from the homomers in their unitary conductance, kinetic behavior, subcellular localization, and response to activation of protein kinase C. Heteromer formation requires the N-terminal domain of Slack-B, one of the alternative splice variants of the Slack channel. This cytoplasmic N-terminal domain of Slack-B also facilitates the localization of heteromeric K(Na) channels to the plasma membrane. Immunocytochemical studies indicate that Slick and Slack-B subunits are coexpressed in many central neurons. Our findings provide a molecular explanation for some of the diversity in reported properties of neuronal K(Na) channels.
Bader,
Sodium-activated potassium current in cultured avian neurones.
, Pubmed
Bader,
Sodium-activated potassium current in cultured avian neurones.
,
Pubmed Bähring,
Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.
2001,
Pubmed Bhattacharjee,
For K+ channels, Na+ is the new Ca2+.
2005,
Pubmed Bhattacharjee,
Localization of the Na+-activated K+ channel Slick in the rat central nervous system.
2005,
Pubmed Bhattacharjee,
Localization of the Slack potassium channel in the rat central nervous system.
2002,
Pubmed Bhattacharjee,
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
2003,
Pubmed
,
Xenbase Bischoff,
Na+-activated K+ channels in small dorsal root ganglion neurones of rat.
1998,
Pubmed Brelidze,
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification.
2003,
Pubmed
,
Xenbase Brown,
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
2008,
Pubmed
,
Xenbase Callsen,
Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].
2005,
Pubmed Cooper,
M-channels: neurological diseases, neuromodulation, and drug development.
2003,
Pubmed Dryer,
A Na+-activated K+ current in cultured brain stem neurones from chicks.
1989,
Pubmed Dryer,
Molecular identification of the Na+-activated K+ channel.
2003,
Pubmed Egan,
Na(+)-activated K+ channels are widely distributed in rat CNS and in Xenopus oocytes.
1992,
Pubmed
,
Xenbase Egan,
Properties and rundown of sodium-activated potassium channels in rat olfactory bulb neurons.
1992,
Pubmed Gulbis,
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
2000,
Pubmed
,
Xenbase Haimann,
Sodium-activated potassium current in sensory neurons: a comparison of cell-attached and cell-free single-channel activities.
1992,
Pubmed Hess,
Characterization of Na+-activated K+ currents in larval lamprey spinal cord neurons.
2007,
Pubmed Hofherr,
Selective Golgi export of Kir2.1 controls the stoichiometry of functional Kir2.x channel heteromers.
2005,
Pubmed Joiner,
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.
1998,
Pubmed Kameyama,
Intracellular Na+ activates a K+ channel in mammalian cardiac cells.
,
Pubmed Kim,
Sodium-activated potassium current in guinea pig gastric myocytes.
2007,
Pubmed Koh,
Na(+)-activated K+ channels localized in the nodal region of myelinated axons of Xenopus.
1994,
Pubmed
,
Xenbase Mao,
Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
2004,
Pubmed
,
Xenbase Nimigean,
Electrostatic tuning of ion conductance in potassium channels.
2003,
Pubmed
,
Xenbase Niu,
Potassium inhibition of sodium-activated potassium (K(Na)) channels in guinea-pig ventricular myocytes.
2000,
Pubmed Paulais,
A Na+- and Cl- -activated K+ channel in the thick ascending limb of mouse kidney.
2006,
Pubmed Pessia,
Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.
1996,
Pubmed
,
Xenbase Phartiyal,
Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition.
2008,
Pubmed
,
Xenbase Rajan,
Sumoylation silences the plasma membrane leak K+ channel K2P1.
2005,
Pubmed
,
Xenbase Rodrigo,
A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.
1990,
Pubmed Safronov,
Properties and functions of Na(+)-activated K+ channels in the soma of rat motoneurones.
1996,
Pubmed Santi,
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
2006,
Pubmed
,
Xenbase Schwake,
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.
2000,
Pubmed
,
Xenbase Tucker,
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
1997,
Pubmed
,
Xenbase Wang,
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.
2007,
Pubmed
,
Xenbase Wang,
Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells.
1991,
Pubmed Wang,
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
1998,
Pubmed
,
Xenbase Yang,
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
2007,
Pubmed Yuan,
The sodium-activated potassium channel is encoded by a member of the Slo gene family.
2003,
Pubmed
,
Xenbase Zerangue,
An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.
2000,
Pubmed
,
Xenbase Zerangue,
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
1999,
Pubmed
,
Xenbase Zhang,
Functional evidence for Na+-activated K+ channels in circular smooth muscle of the opossum lower esophageal sphincter.
2007,
Pubmed Zheng,
Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels.
1998,
Pubmed
,
Xenbase Zhou,
Developmental regulation of a Na(+)-activated fast outward K+ current in rat myoblasts.
2004,
Pubmed
