XB-ART-40176
Dev Dyn
2009 Aug 01;2388:1984-98. doi: 10.1002/dvdy.22031.
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Emx3 is required for the differentiation of dorsal telencephalic neurons.
Viktorin G, Chiuchitu C, Rissler M, Varga ZM, Westerfield M.
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emx3 is first expressed in prospective telencephalic cells at the anterior border of the zebrafish neural plate. Knockdown of Emx3 function by morpholino reduces the expression of markers specific to dorsal telencephalon, and impairs axon tract formation. Rescue of both early and late markers requires low-level expression of emx3 at the one- or two-somite stage. Higher emx3 expression levels cause dorsal telencephalic markers to expand ventrally, which points to a possible role of emx3 in specifying dorsal telencephalon and a potential new function for Wnt/beta-catenin pathway activation. In contrast to mice, where Emx2 plays a major role in dorsal telencephalic development, knockdown of zebrafish Emx2 apparently does not affect telencephalic development. Similarly, Emx1 knockdown has little effect. Previously, emx3 was thought to be fish-specific. However, we found all three emx orthologs in Xenopus tropicalis and opossum (Monodelphis domestica) genomes, indicating that emx3 was present in an ancestral tetrapod genome.
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???displayArticle.pmcLink??? PMC2975037
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???displayArticle.grants??? [+]
DC04186 NIDCD NIH HHS , HD22486 NICHD NIH HHS , P01 HD022486-17 NICHD NIH HHS , R01 DC004186-11 NIDCD NIH HHS , P01 HD022486 NICHD NIH HHS , R01 DC004186 NIDCD NIH HHS
Species referenced: Xenopus tropicalis
Genes referenced: emx1 emx1l emx2
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