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Metazoan organisms can 'scale', that is, maintain similar proportions regardless of size. Ben-Zvi et al. use experiments in Xenopus to support a quantitative model that explains morphological scaling as the result of scaling of a gradient of bone morphogenetic protein (BMP) signals. We believe that the evidence for scaling in Xenopus is misinterpreted, and that their model for embryonic patterning disagrees with prior data. The experiments they present supporting their model admit alternative interpretations.
Ben-Zvi,
Scaling of the BMP activation gradient in Xenopus embryos.
2008, Pubmed,
Xenbase
Ben-Zvi,
Scaling of the BMP activation gradient in Xenopus embryos.
2008,
Pubmed
,
Xenbase Cooke,
Scale of body pattern adjusts to available cell number in amphibian embryos.
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Pubmed
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Xenbase Faure,
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Changing the axis changes the perspective.
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Xenbase Kinoshita,
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Pubmed
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Xenbase Marom,
Temporal analysis of the early BMP functions identifies distinct anti-organizer and mesoderm patterning phases.
2005,
Pubmed
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Xenbase Meinhardt,
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Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos.
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Pubmed
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Xenbase Reversade,
Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.
2005,
Pubmed
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Xenbase Reversade,
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
2005,
Pubmed
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Xenbase Schohl,
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Pubmed
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Xenbase Solnica-Krezel,
Vertebrate development: taming the nodal waves.
2003,
Pubmed Tucker,
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis.
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Pubmed Williams,
Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo.
2004,
Pubmed
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Xenbase
