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Figure 1. Scheme of the structure of PTEN and Ci-VSP. Ci-VSP has an active center for catalysis with one amino acid difference from PTEN (HCKGGK for Ci-VSP and HCKAGK for PTEN). Both proteins contain a phosphoinositide-binding motif (PBM) with KRR and C2 domains that are known to associate with membrane. Although it is not depicted in the figure, Ci-VSP contains another pair of arginines at residues 245 and 246 that is not conserved in PTEN.
Begley,
The structure and regulation of myotubularin phosphatases.
2005, Pubmed
Begley,
The structure and regulation of myotubularin phosphatases.
2005,
Pubmed Campbell,
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.
2003,
Pubmed Halaszovich,
Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase.
2009,
Pubmed Hossain,
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases.
2008,
Pubmed
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Xenbase Iijima,
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.
2004,
Pubmed Iwasaki,
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate.
2008,
Pubmed
,
Xenbase Kohout,
Subunit organization and functional transitions in Ci-VSP.
2008,
Pubmed Lee,
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
1999,
Pubmed
,
Xenbase Maehama,
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
1998,
Pubmed Maehama,
PTEN and myotubularin: novel phosphoinositide phosphatases.
2001,
Pubmed Merlot,
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi.
2003,
Pubmed Murata,
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor.
2005,
Pubmed
,
Xenbase Murata,
Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2.
2007,
Pubmed
,
Xenbase Okamura,
Biodiversity of voltage sensor domain proteins.
2007,
Pubmed Okamura,
Voltage-sensing phosphatase: actions and potentials.
2009,
Pubmed Pagliarini,
A PTEN-like phosphatase with a novel substrate specificity.
2004,
Pubmed Rahdar,
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
2009,
Pubmed Redfern,
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.
2008,
Pubmed Vazquez,
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.
2006,
Pubmed Villalba-Galea,
S4-based voltage sensors have three major conformations.
2008,
Pubmed Villalba-Galea,
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.
2009,
Pubmed
,
Xenbase Walker,
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
2004,
Pubmed
