C R Biol 2003 Jan 01;32610-11:1011-7. doi: 10.1016/j.crvi.2003.09.019.

In situ analysis of gene expression in Xenopus embryos.

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The molecular anatomy of the vertebrate embryo was systematically analysed through gene expression during early development of the Xenopus frog using whole-mount in situ hybridization. Expression patterns are documented and assembled into the database Axeldb (http://www.dkfz-heidelberg.de/abt0135/axeldb.htm). Synexpression groups representing genes with shared, complex expression pattern that predict molecular pathways involved in patterning and differentiation have been identified. These sets of co-regulated genes show a striking similarity with operons, and may be a key determinant facilitating evolutionary change leading to animal diversity.

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Species referenced: Xenopus
Genes referenced: bmp4 dll1 post prdm1