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Neuron
2009 Nov 25;644:471-83. doi: 10.1016/j.neuron.2009.09.025.
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Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.
Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL, Worley PF.
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Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous system, where their physiological function as isomerases remains unknown. We demonstrate that FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening. FKBP52 mediates stimulus-dependent TRPC1 gating through isomerization, which is required for chemotropic turning of neuronal growth cones to netrin-1 and myelin-associated glycoprotein and for netrin-1/DCC-dependent midline axon guidance of commissural interneurons in the developing spinal cord. By contrast, FKBP12 mediates spontaneous opening of TRPC1 through isomerization and is not required for growth cone responses to netrin-1. Our study demonstrates a novel physiological function of proline isomerases in chemotropic nerve guidance through TRPC1 gating and may have significant implication in clinical applications of immunophilin-related therapeutic drugs.
Barik,
Immunophilins: for the love of proteins.
2006, Pubmed
Barik,
Immunophilins: for the love of proteins.
2006,
Pubmed Bosco,
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.
2002,
Pubmed Clapham,
TRP channels as cellular sensors.
2003,
Pubmed Davies,
FKBP52.
2005,
Pubmed Delaglio,
NMRPipe: a multidimensional spectral processing system based on UNIX pipes.
1995,
Pubmed Farrow,
A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibrium.
1994,
Pubmed Fischer,
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins.
1989,
Pubmed Gkika,
The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5.
2006,
Pubmed Goel,
Regulation of Drosophila TRPL channels by immunophilin FKBP59.
2001,
Pubmed Goh,
beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.
2008,
Pubmed Gold,
Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.
1999,
Pubmed Göthel,
Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts.
1999,
Pubmed Harding,
A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.
1989,
Pubmed Hong,
Calcium signalling in the guidance of nerve growth by netrin-1.
2000,
Pubmed
,
Xenbase Huang,
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.
2006,
Pubmed Johnson,
NMR View: A computer program for the visualization and analysis of NMR data.
1994,
Pubmed Kern,
The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin.
1993,
Pubmed Kiselyov,
The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels.
1999,
Pubmed Leung,
Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.
2006,
Pubmed
,
Xenbase Li,
Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.
2005,
Pubmed
,
Xenbase Liu,
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.
1991,
Pubmed Lohof,
Asymmetric modulation of cytosolic cAMP activity induces growth cone turning.
1992,
Pubmed
,
Xenbase Macura,
Two-dimensional exchange spectroscopy of proteins.
1994,
Pubmed McKerracher,
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.
1994,
Pubmed Mikoshiba,
IP3 receptor/Ca2+ channel: from discovery to new signaling concepts.
2007,
Pubmed Ming,
cAMP-dependent growth cone guidance by netrin-1.
1997,
Pubmed
,
Xenbase Ming,
Adaptation in the chemotactic guidance of nerve growth cones.
2002,
Pubmed
,
Xenbase Ming,
Turning by asymmetric actin.
2006,
Pubmed Miniero,
Pregnancy after renal transplantation in Italian patients: focus on fetal outcome.
2002,
Pubmed Moon,
Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing.
2005,
Pubmed
,
Xenbase Muchmore,
Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance.
1989,
Pubmed Mukhopadhyay,
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.
1994,
Pubmed Nilius,
Transient receptor potential cation channels in disease.
2007,
Pubmed Phelps,
Ventrally located commissural neurons express the GABAergic phenotype in developing rat spinal cord.
1999,
Pubmed Reimer,
Conformational state of a 25-mer peptide from the cyclophilin-binding loop of the HIV type 1 capsid protein.
1997,
Pubmed Schiene-Fischer,
Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases.
2001,
Pubmed Serafini,
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.
1996,
Pubmed Shim,
XTRPC1-dependent chemotropic guidance of neuronal growth cones.
2005,
Pubmed
,
Xenbase Siekierka,
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin.
1989,
Pubmed Sinkins,
Association of immunophilins with mammalian TRPC channels.
2004,
Pubmed Snyder,
Immunophilins in the nervous system.
1998,
Pubmed Song,
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
1998,
Pubmed
,
Xenbase Song,
Astroglia induce neurogenesis from adult neural stem cells.
2002,
Pubmed Song,
Signal transduction underlying growth cone guidance by diffusible factors.
1999,
Pubmed Steiner,
High brain densities of the immunophilin FKBP colocalized with calcineurin.
1992,
Pubmed Takahashi,
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin.
1989,
Pubmed Venkatachalam,
TRP channels.
2007,
Pubmed Wang,
Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones.
2005,
Pubmed
,
Xenbase Xiao,
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.
1998,
Pubmed
,
Xenbase Yuan,
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.
2003,
Pubmed Yuan,
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
2007,
Pubmed Zeng,
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.
2008,
Pubmed Zheng,
Turning of nerve growth cones induced by localized increases in intracellular calcium ions.
2000,
Pubmed
,
Xenbase Zheng,
Turning of nerve growth cones induced by neurotransmitters.
1994,
Pubmed
,
Xenbase
