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???displayArticle.abstract??? Somites give rise to the vertebral column and segmented musculature of adult vertebrates. The cell movements that position cells within somites along the anteroposterior and dorsoventral axes are not well understood. Using a fate mapping approach, we show that at the onset of Xenopus laevis gastrulation, mesoderm cells undergo distinct cell movements to form myotome fibers positioned in discrete locations within somites and along the anteroposterior axis. We show that the distribution of presomitic cells along the anteroposterior axis is influenced by convergent and extension movements of the notochord. Heterochronic and heterotopic transplantations between presomitic gastrula and early tail bud stages show that these cells are interchangeable and can form myotome fibers in locations determined by the host embryo. However, additional transplantation experiments revealed differences in the competency of presomitic cells to form myotome fibers, suggesting that maturation within the tail budpresomitic mesoderm is required for myotome fiber differentiation.
Afonin,
Cell behaviors associated with somite segmentation and rotation in Xenopus laevis.
2006, Pubmed,
Xenbase
Afonin,
Cell behaviors associated with somite segmentation and rotation in Xenopus laevis.
2006,
Pubmed
,
Xenbase Bolce,
Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin.
1992,
Pubmed
,
Xenbase Dale,
Regional specification within the mesoderm of early embryos of Xenopus laevis.
1987,
Pubmed
,
Xenbase Dale,
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock.
2003,
Pubmed Danilchick,
Xenopus laevis: Practical uses in cell and molecular biology. Pictorial collage of embryonic stages.
1991,
Pubmed
,
Xenbase Dosch,
Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus.
1997,
Pubmed
,
Xenbase Drake,
Perturbation of beta 1 integrin-mediated adhesions results in altered somite cell shape and behavior.
1992,
Pubmed Forlani,
Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo.
2003,
Pubmed Harland,
Formation and function of Spemann's organizer.
1997,
Pubmed Hemmati-Brivanlou,
Inhibition of activin receptor signaling promotes neuralization in Xenopus.
1994,
Pubmed
,
Xenbase Henry,
Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction.
2000,
Pubmed Hidalgo,
In vivo analyzes of dystroglycan function during somitogenesis in Xenopus laevis.
2009,
Pubmed
,
Xenbase Iimura,
Establishment of Hox vertebral identities in the embryonic spine precursors.
2009,
Pubmed Iimura,
Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression.
2006,
Pubmed Iimura,
Dual mode of paraxial mesoderm formation during chick gastrulation.
2007,
Pubmed Joos,
Integrin alpha 5 during early development of Xenopus laevis.
1995,
Pubmed
,
Xenbase Keller,
Cell intercalation during notochord development in Xenopus laevis.
1989,
Pubmed
,
Xenbase Keller,
Early embryonic development of Xenopus laevis.
1991,
Pubmed
,
Xenbase Kintner,
Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.
,
Pubmed
,
Xenbase Koshida,
Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.
2005,
Pubmed Kragtorp,
Integrin alpha5 is required for somite rotation and boundary formation in Xenopus.
2007,
Pubmed
,
Xenbase Krumlauf,
Hox genes in vertebrate development.
1994,
Pubmed Kulesa,
Cell dynamics during somite boundary formation revealed by time-lapse analysis.
2002,
Pubmed Lane,
Primitive and definitive blood share a common origin in Xenopus: a comparison of lineage techniques used to construct fate maps.
2002,
Pubmed
,
Xenbase Lane,
Designation of the anterior/posterior axis in pregastrula Xenopus laevis.
2000,
Pubmed
,
Xenbase Lane,
The origins of primitive blood in Xenopus: implications for axial patterning.
1999,
Pubmed
,
Xenbase Marsden,
Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus.
2003,
Pubmed
,
Xenbase McGrew,
Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity.
2008,
Pubmed Saka,
Spatial and temporal patterns of cell division during early Xenopus embryogenesis.
2001,
Pubmed
,
Xenbase Sato,
Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation.
2002,
Pubmed Sato,
A novel signal induces a segmentation fissure by acting in a ventral-to-dorsal direction in the presomitic mesoderm.
2005,
Pubmed Shook,
Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis.
2004,
Pubmed
,
Xenbase Vincent,
Subcortical rotation in Xenopus eggs: an early step in embryonic axis specification.
1987,
Pubmed
,
Xenbase Wacker,
Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation.
2004,
Pubmed
,
Xenbase Wellik,
Hox patterning of the vertebrate axial skeleton.
2007,
Pubmed Wunderlich,
Muscle specification in the Xenopus laevis gastrula-stage embryo.
2005,
Pubmed
,
Xenbase Yang,
Embryonic mesodermal defects in alpha 5 integrin-deficient mice.
1993,
Pubmed Youn,
Somitogenesis in the amphibian Xenopus laevis: scanning electron microscopic analysis of intrasomitic cellular arrangements during somite rotation.
1981,
Pubmed
,
Xenbase Zagris,
Developmentally regulated expression and functional role of alpha 7 integrin in the chick embryo.
2004,
Pubmed
