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Cold Spring Harb Perspect Biol
2009 Nov 01;15:a001990. doi: 10.1101/cshperspect.a001990.
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Robust generation and decoding of morphogen gradients.
Barkai N, Shilo BZ.
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Morphogen gradients play a key role in multiple differentiation processes. Both the formation of the gradient and its interpretation by the receiving cells need to occur at high precision to ensure reproducible patterning. This need for quantitative precision is challenged by fluctuations in the environmental conditions and by variations in the genetic makeup of the developing embryos. We discuss mechanisms that buffer morphogen profiles against variations in gene dosage. Self-enhanced morphogen degradation and pre-steady-state decoding provide general means for buffering the morphogen profile against fluctuations in morphogen production rate. A more specific "shuttling" mechanism, which establishes a sharp and robust activation profile of a widely expressed morphogen, and enables the adjustment of morphogen profile with embryo size, is also described. Finally, we consider the transformation of the smooth gradient profile into sharp borders of gene expression in the signal-receiving cells. The integration theory and experiments are increasingly used, providing key insights into the system-level functioning of the developmental system.
Akiyama,
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface.
2008, Pubmed
Akiyama,
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface.
2008,
Pubmed Barkai,
'Big frog, small frog'--maintaining proportions in embryonic development: delivered on 2 July 2008 at the 33rd FEBS Congress in Athens, Greece.
2009,
Pubmed
,
Xenbase Ben-Zvi,
Scaling of the BMP activation gradient in Xenopus embryos.
2008,
Pubmed
,
Xenbase Bergmann,
Pre-steady-state decoding of the Bicoid morphogen gradient.
2007,
Pubmed Bergmann,
Re-examining the stability of the Bicoid morphogen gradient.
2008,
Pubmed Bollenbach,
Robust formation of morphogen gradients.
2005,
Pubmed Chen,
Dual roles for patched in sequestering and transducing Hedgehog.
1996,
Pubmed Cooke,
Scale of body pattern adjusts to available cell number in amphibian embryos.
1981,
Pubmed
,
Xenbase De Robertis,
Dorsal-ventral patterning and neural induction in Xenopus embryos.
2004,
Pubmed
,
Xenbase De Robertis,
Spemann's organizer and self-regulation in amphibian embryos.
2006,
Pubmed Dessaud,
Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.
2007,
Pubmed Driever,
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen.
1989,
Pubmed Driever,
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo.
1989,
Pubmed Driever,
Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequences.
1989,
Pubmed Driever,
A gradient of bicoid protein in Drosophila embryos.
1988,
Pubmed Driever,
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner.
1988,
Pubmed Eldar,
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
2002,
Pubmed Eldar,
Self-enhanced ligand degradation underlies robustness of morphogen gradients.
2003,
Pubmed Ephrussi,
Seeing is believing: the bicoid morphogen gradient matures.
2004,
Pubmed Ferguson,
Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.
1992,
Pubmed Gabay,
EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm.
1996,
Pubmed Goldbeter,
Covalent modification of proteins as a threshold mechanism in development.
1990,
Pubmed Goldbeter,
An amplified sensitivity arising from covalent modification in biological systems.
1981,
Pubmed Gregor,
Probing the limits to positional information.
2007,
Pubmed Gregor,
Stability and nuclear dynamics of the bicoid morphogen gradient.
2007,
Pubmed Holley,
Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms.
1997,
Pubmed
,
Xenbase Holley,
The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.
1996,
Pubmed
,
Xenbase Houchmandzadeh,
Establishment of developmental precision and proportions in the early Drosophila embryo.
2002,
Pubmed Incardona,
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1.
2000,
Pubmed Jiang,
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen.
1993,
Pubmed Lucchetta,
Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics.
2005,
Pubmed Meinhardt,
Developmental biology: sharp peaks from shallow sources.
2002,
Pubmed Melen,
Threshold responses to morphogen gradients by zero-order ultrasensitivity.
2005,
Pubmed Mizutani,
Formation of the BMP activity gradient in the Drosophila embryo.
2005,
Pubmed O'Connor,
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing.
2006,
Pubmed Raftery,
TGF-beta family signal transduction in Drosophila development: from Mad to Smads.
1999,
Pubmed Reversade,
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
2005,
Pubmed
,
Xenbase Rivera-Pomar,
From gradients to stripes in Drosophila embryogenesis: filling in the gaps.
1996,
Pubmed Saha,
Signal dynamics in Sonic hedgehog tissue patterning.
2006,
Pubmed Shimmi,
Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo.
2005,
Pubmed Srinivasan,
Creation of a Sog morphogen gradient in the Drosophila embryo.
2002,
Pubmed St Johnston,
The origin of pattern and polarity in the Drosophila embryo.
1992,
Pubmed Struhl,
The gradient morphogen bicoid is a concentration-dependent transcriptional activator.
1989,
Pubmed Tabata,
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.
1994,
Pubmed Teleman,
Shaping morphogen gradients.
2001,
Pubmed Tsuda,
The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila.
1999,
Pubmed van der Zee,
Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.
2006,
Pubmed Wang,
Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.
2005,
Pubmed White,
Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo.
2007,
Pubmed Wolpert,
Positional information revisited.
1989,
Pubmed
