Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Stem Cells
2010 Nov 01;2811:2073-83. doi: 10.1002/stem.529.
Show Gene links
Show Anatomy links
An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development.
???displayArticle.abstract???
Organ-specific adult stem cells are critical for the homeostasis of adult organs and organ repair and regeneration. Unfortunately, it has been difficult to investigate the origins of these stem cells and the mechanisms of their development, especially in mammals. Intestinal remodeling during frog metamorphosis offers a unique opportunity for such studies. During the transition from an herbivorous tadpole to a carnivorous frog, the intestine is completely remodeled as the larval epithelial cells undergo apoptotic degeneration and are replaced by adult epithelial cells developed de novo. The entire metamorphic process is under the control of thyroid hormone, making it possible to control the development of the adult intestinal stem cells. Here, we show that the thyroid hormone receptor-coactivator protein arginine methyltransferase 1 (PRMT1) is upregulated in a small number of larval epithelial cells and that these cells dedifferentiate to become the adult stem cells. More importantly, transgenic overexpression of PRMT1 leads to increased adult stem cells in the intestine, and conversely, knocking down the expression of endogenous PRMT1 reduces the adult stem cell population. In addition, PRMT1 expression pattern during zebrafish and mouse development suggests that PRMT1 may play an evolutionally conserved role in the development of adult intestinal stem cells throughout vertebrates. These findings are not only important for the understanding of organ-specific adult stem cell development but also have important implications in regenerative medicine of the digestive tract.
Amano,
Metamorphosis-associated and region-specific expression of calbindin gene in the posterior intestinal epithelium of Xenopus laevis larva.
1998, Pubmed,
Xenbase
Amano,
Metamorphosis-associated and region-specific expression of calbindin gene in the posterior intestinal epithelium of Xenopus laevis larva.
1998,
Pubmed
,
Xenbase Batut,
The Ca2+-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo.
2005,
Pubmed
,
Xenbase BONNEVILLE,
FINE STRUCTURAL CHANGES IN THE INTESTINAL EPITHELIUM OF THE BULLFROG DURING METAMORPHOSIS.
1963,
Pubmed Brown,
Amphibian metamorphosis.
2007,
Pubmed
,
Xenbase Brown,
The role of thyroid hormone in zebrafish and axolotl development.
1997,
Pubmed Buchholz,
Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.
2004,
Pubmed
,
Xenbase Buchholz,
Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.
2006,
Pubmed
,
Xenbase Buchholz,
A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.
2003,
Pubmed
,
Xenbase Burke,
Co-repressors 2000.
2000,
Pubmed Chen,
Regulation of transcription by a protein methyltransferase.
1999,
Pubmed Cheung,
Protein arginine-methyltransferase-dependent oncogenesis.
2007,
Pubmed El Messaoudi,
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.
2006,
Pubmed Friedrichsen,
Regulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidism.
2003,
Pubmed Fu,
Novel double promoter approach for identification of transgenic animals: A tool for in vivo analysis of gene function and development of gene-based therapies.
2002,
Pubmed
,
Xenbase Havis,
Metamorphic T3-response genes have specific co-regulator requirements.
2003,
Pubmed
,
Xenbase Hu,
Transcriptional repression by nuclear hormone receptors.
2000,
Pubmed Ishizuya-Oka,
Thyroid hormone-upregulated expression of Musashi-1 is specific for progenitor cells of the adult epithelium during amphibian gastrointestinal remodeling.
2003,
Pubmed
,
Xenbase Ishizuya-Oka,
Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis.
2009,
Pubmed
,
Xenbase Ishizuya-Oka,
Anteroposterior gradient of epithelial transformation during amphibian intestinal remodeling: immunohistochemical detection of intestinal fatty acid-binding protein.
1997,
Pubmed
,
Xenbase Ishizuya-Oka,
Apoptosis and cell proliferation in the Xenopus small intestine during metamorphosis.
1996,
Pubmed
,
Xenbase Ishizuya-Oka,
Induction of metamorphosis by thyroid hormone in anuran small intestine cultured organotypically in vitro.
1991,
Pubmed
,
Xenbase Ito,
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function.
2001,
Pubmed Jepsen,
Biological roles and mechanistic actions of co-repressor complexes.
2002,
Pubmed Jones,
N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors.
2003,
Pubmed
,
Xenbase Lazar,
Thyroid hormone receptors: multiple forms, multiple possibilities.
1993,
Pubmed Lee,
Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation.
2009,
Pubmed Li,
Design and synthesis of dendritic molecular transporter that achieves efficient in vivo delivery of morpholino antisense oligo.
2008,
Pubmed MACDONALD,
CELL PROLIFERATION AND MIGRATION IN THE STOMACH, DUODENUM, AND RECTUM OF MAN: RADIOAUTOGRAPHIC STUDIES.
1964,
Pubmed Mangelsdorf,
The nuclear receptor superfamily: the second decade.
1995,
Pubmed Matsuda,
Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis.
2009,
Pubmed
,
Xenbase Matsuda,
An epidermal signal regulates Lmx-1 expression and dorsal-ventral pattern during Xenopus limb regeneration.
2001,
Pubmed
,
Xenbase Matsuda,
Contrasting effects of two alternative splicing forms of coactivator-associated arginine methyltransferase 1 on thyroid hormone receptor-mediated transcription in Xenopus laevis.
2007,
Pubmed
,
Xenbase Papadokostopoulou,
Colon cancer and protein arginine methyltransferase 1 gene expression.
2009,
Pubmed Paul,
SRC-p300 coactivator complex is required for thyroid hormone-induced amphibian metamorphosis.
2007,
Pubmed
,
Xenbase Paul,
Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis.
2003,
Pubmed
,
Xenbase Paul,
Coactivator recruitment is essential for liganded thyroid hormone receptor to initiate amphibian metamorphosis.
2005,
Pubmed
,
Xenbase Paul,
Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.
2005,
Pubmed
,
Xenbase Pawlak,
Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable.
2000,
Pubmed Pei,
Regulation of pluripotency and reprogramming by transcription factors.
2009,
Pubmed Rachez,
Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.
2000,
Pubmed Rachez,
Mediator complexes and transcription.
2001,
Pubmed Sachs,
Nuclear receptor corepressor recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis development.
2002,
Pubmed
,
Xenbase Sancho,
Signaling pathways in intestinal development and cancer.
2004,
Pubmed Sato,
A role of unliganded thyroid hormone receptor in postembryonic development in Xenopus laevis.
2007,
Pubmed
,
Xenbase Schreiber,
Remodeling of the intestine during metamorphosis of Xenopus laevis.
2005,
Pubmed
,
Xenbase Schreiber,
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
2001,
Pubmed
,
Xenbase Shi,
Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes.
2009,
Pubmed
,
Xenbase Shi,
Biphasic intestinal development in amphibians: embryogenesis and remodeling during metamorphosis.
1996,
Pubmed
,
Xenbase Shi,
Thyroid hormone regulation of apoptotic tissue remodeling: implications from molecular analysis of amphibian metamorphosis.
2001,
Pubmed
,
Xenbase Suzuki,
Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK/ERK and PI3K/AKT pathways in blastema formation during limb regeneration.
2007,
Pubmed
,
Xenbase Takahashi,
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
2006,
Pubmed Tata,
Gene expression during metamorphosis: an ideal model for post-embryonic development.
1993,
Pubmed Tomita,
Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development.
2004,
Pubmed
,
Xenbase Tsai,
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
1994,
Pubmed van der Flier,
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
2009,
Pubmed Yen,
Physiological and molecular basis of thyroid hormone action.
2001,
Pubmed Yu,
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
2009,
Pubmed Zhang,
The mechanism of action of thyroid hormones.
2000,
Pubmed Zhou,
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
2008,
Pubmed Zhou,
Extreme makeover: converting one cell into another.
2008,
Pubmed
