Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nat Cell Biol
2011 Jun 01;136:676-85. doi: 10.1038/ncb2255.
Show Gene links
Show Anatomy links
Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites.
Nishiyama M, Togashi K, von Schimmelmann MJ, Lim CS, Maeda S, Yamashita N, Goshima Y, Ishii S, Hong K.
???displayArticle.abstract???
Polarized neurites (axons and dendrites) form the functional circuitry of the nervous system. Secreted guidance cues often control the polarity of neuron migration and neurite outgrowth by regulating ion channels. Here, we show that secreted semaphorin 3A (Sema3A) induces the neurite identity of Xenopus spinal commissural interneurons (xSCINs) by activating Ca(V)2.3 channels (Ca(V)2.3). Sema3A treatment converted the identity of axons of cultured xSCINs to that of dendrites by recruiting functional Ca(V)2.3. Inhibition of Sema3A signalling prevented both the expression of Ca(V)2.3 and acquisition of the dendrite identity, and inhibition of Ca(V)2.3 function resulted in multiple axon-like neurites of xSCINs in the spinal cord. Furthermore, Sema3A-triggered cGMP production and PKG activity induced, respectively, the expression of functional Ca(V)2.3 and the dendrite identity. These results reveal a mechanism by which a guidance cue controls the identity of neurites during nervous system development.
Adler,
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation.
2006, Pubmed
Adler,
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation.
2006,
Pubmed Arimura,
Neuronal polarity: from extracellular signals to intracellular mechanisms.
2007,
Pubmed Barnes,
Establishment of axon-dendrite polarity in developing neurons.
2009,
Pubmed Barnes,
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
2007,
Pubmed Bradke,
Differentiated neurons retain the capacity to generate axons from dendrites.
2000,
Pubmed Campbell,
Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones.
2003,
Pubmed
,
Xenbase Campbell,
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.
2001,
Pubmed
,
Xenbase Craig,
Neuronal polarity.
1994,
Pubmed Esch,
Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons.
1999,
Pubmed Fenstermaker,
Regulation of dendritic length and branching by semaphorin 3A.
2004,
Pubmed Gomis-Rüth,
Plasticity of polarization: changing dendrites into axons in neurons integrated in neuronal circuits.
2008,
Pubmed Goshima,
A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse.
1997,
Pubmed Gu,
Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons.
1993,
Pubmed
,
Xenbase Guan,
Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.
2007,
Pubmed Henley,
Guiding neuronal growth cones using Ca2+ signals.
2004,
Pubmed Hong,
Calcium signalling in the guidance of nerve growth by netrin-1.
2000,
Pubmed
,
Xenbase Hong,
From guidance signals to movement: signaling molecules governing growth cone turning.
2010,
Pubmed Jan,
The control of dendrite development.
2003,
Pubmed Jiang,
Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.
2005,
Pubmed Jiménez-González,
Development of Ca2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis.
2003,
Pubmed
,
Xenbase Kaneko,
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.
2006,
Pubmed Li,
Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
2007,
Pubmed
,
Xenbase Li,
Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals.
2001,
Pubmed
,
Xenbase Liu,
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
2002,
Pubmed Magee,
Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons.
1995,
Pubmed Marín,
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
2001,
Pubmed Moon,
Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing.
2005,
Pubmed
,
Xenbase Morita,
Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.
2006,
Pubmed Nishiyama,
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.
2003,
Pubmed
,
Xenbase Nishiyama,
Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning.
2008,
Pubmed
,
Xenbase Pham,
The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP.
2000,
Pubmed Piper,
Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation.
2005,
Pubmed
,
Xenbase Polleux,
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
2000,
Pubmed Poon,
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.
2008,
Pubmed Roberts,
Development and characterization of commissural interneurones in the spinal cord of Xenopus laevis embryos revealed by antibodies to glycine.
1988,
Pubmed
,
Xenbase Roberts,
The early development of neurons with GABA immunoreactivity in the CNS of Xenopus laevis embryos.
1987,
Pubmed
,
Xenbase Sabatini,
Analysis of calcium channels in single spines using optical fluctuation analysis.
2000,
Pubmed Shelly,
LKB1/STRAD promotes axon initiation during neuronal polarization.
2007,
Pubmed Shelly,
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation.
2010,
Pubmed Song,
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
1998,
Pubmed
,
Xenbase Song,
A selective filter for cytoplasmic transport at the axon initial segment.
2009,
Pubmed Stein,
RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.
2001,
Pubmed
,
Xenbase Stornetta,
Ras and Rap signaling in synaptic plasticity and mental disorders.
2011,
Pubmed Togashi,
Cyclic GMP-gated CNG channels function in Sema3A-induced growth cone repulsion.
2008,
Pubmed
,
Xenbase Tran,
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
2009,
Pubmed Uchida,
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.
2005,
Pubmed Yi,
TGF-beta signaling specifies axons during brain development.
2010,
Pubmed Yoshimura,
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
2005,
Pubmed
