Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Periostin (postn) is a secreted, extracellular matrix protein containing an EMI domain as well as four fasciclin I-like (Fas1) domains. Postn protein functions in cell adhesion, cell mobility, cell proliferation and gene regulation. Earlier studies have shown that postn is involved in different developmental processes such as somitogenesis, cardiogenesis and bone formation. Intriguingly, postn seems to be a very good candidate to establish novel therapies against cancer and chronic heart defects. Here we describe for the first time the spatio-temporal expression profile of postn during early development of Xenopus laevis. By semi-quantitative RT-PCR approaches, we demonstrate that postn is maternally expressed. Zygotic expression starts during early gastrulation and increases until stage 40. Whole mount in situ hybridization experiments revealed that postn is detectable in somites, the sensory layer of the epidermis, the roof plate, the notochord, the heart, migrating neural crest cells, cranial ganglia and forming cranial cartilage structures. Our results implicate a role of postn during Xenopus embryogenesis and represent a good starting point for future functional analyses.
Gillan,
Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.
2002, Pubmed
Gillan,
Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.
2002,
Pubmed Goto,
Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development.
2000,
Pubmed
,
Xenbase Horiuchi,
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta.
1999,
Pubmed Kudo,
Zebrafish periostin is required for the adhesion of muscle fiber bundles to the myoseptum and for the differentiation of muscle fibers.
2004,
Pubmed Kühn,
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair.
2007,
Pubmed Lindner,
Vascular injury induces expression of periostin: implications for vascular cell differentiation and migration.
2005,
Pubmed Lorts,
Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.
2009,
Pubmed Norris,
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.
2007,
Pubmed Park,
Expression analysis of Runx3 and other Runx family members during Xenopus development.
2010,
Pubmed
,
Xenbase Ruan,
The multifaceted role of periostin in tumorigenesis.
2009,
Pubmed Shimazaki,
Periostin is essential for cardiac healing after acute myocardial infarction.
2008,
Pubmed Snider,
Origin of cardiac fibroblasts and the role of periostin.
2009,
Pubmed Snider,
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
2008,
Pubmed Takeshita,
Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I.
1993,
Pubmed Zhu,
Immunolocalization of Periostin-like factor and Periostin during embryogenesis.
2008,
Pubmed
