Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Endocrinology
2012 Feb 01;1532:961-72. doi: 10.1210/en.2011-1736.
Show Gene links
Show Anatomy links
Liganded thyroid hormone receptor induces nucleosome removal and histone modifications to activate transcription during larval intestinal cell death and adult stem cell development.
???displayArticle.abstract??? Thyroid hormone (T(3)) plays an important role in regulating multiple cellular and metabolic processes, including cell proliferation, cell death, and energy metabolism, in vertebrates. Dysregulation of T(3) signaling results in developmental abnormalities, metabolic defects, and even cancer. We used T(3)-dependent Xenopus metamorphosis as a model to study how T(3) regulates transcription during vertebrate development. T(3) exerts its metamorphic effects through T(3) receptors (TR). TR recruits, in a T(3)-dependent manner, cofactor complexes that can carry out chromatin remodeling/histone modifications. Whether and how histone modifications change upon gene regulation by TR during vertebrate development is largely unknown. Here we analyzed histone modifications at T(3) target genes during intestinal metamorphosis, a process that involves essentially total apoptotic degeneration of the simple larval epithelium and de novo development of the adult epithelial stem cells, followed by their proliferation and differentiation into the complex adult epithelium. We demonstrated for the first time in vivo during vertebrate development that TR induces the removal of core histones at the promoter region and the recruitment of RNA polymerase. Furthermore, a number of histone activation and repression marks have been defined based on correlations with mRNA levels in cell cultures. Most but not all correlate with gene expression induced by liganded TR during development, suggesting that tissue and developmental context influences the roles of histone modifications in gene regulation. Our findings provide important mechanistic insights on how chromatin remodeling affects developmental gene regulation in vivo.
Barski,
High-resolution profiling of histone methylations in the human genome.
2007, Pubmed
Barski,
High-resolution profiling of histone methylations in the human genome.
2007,
Pubmed Barth,
Fast signals and slow marks: the dynamics of histone modifications.
2010,
Pubmed Bilesimo,
Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses.
2011,
Pubmed
,
Xenbase Buchholz,
Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.
2004,
Pubmed
,
Xenbase Buchholz,
Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis.
2004,
Pubmed
,
Xenbase Buchholz,
A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.
2003,
Pubmed
,
Xenbase Buchholz,
Gene-specific changes in promoter occupancy by thyroid hormone receptor during frog metamorphosis. Implications for developmental gene regulation.
2005,
Pubmed
,
Xenbase Buchholz,
Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.
2006,
Pubmed
,
Xenbase Burke,
Co-repressors 2000.
2000,
Pubmed Cao,
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.
2004,
Pubmed Cao,
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
2002,
Pubmed Das,
Identification of direct thyroid hormone response genes reveals the earliest gene regulation programs during frog metamorphosis.
2009,
Pubmed
,
Xenbase Furlow,
In vitro and in vivo analysis of the regulation of a transcription factor gene by thyroid hormone during Xenopus laevis metamorphosis.
1999,
Pubmed
,
Xenbase Hasebe,
Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine.
2011,
Pubmed
,
Xenbase Havis,
Metamorphic T3-response genes have specific co-regulator requirements.
2003,
Pubmed
,
Xenbase Heimeier,
Participation of Brahma-related gene 1 (BRG1)-associated factor 57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development.
2008,
Pubmed
,
Xenbase Hsia,
Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor.
2002,
Pubmed
,
Xenbase Hu,
Transcriptional repression by nuclear hormone receptors.
2000,
Pubmed Huang,
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription.
2003,
Pubmed
,
Xenbase Ishizuya-Oka,
Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis.
2009,
Pubmed
,
Xenbase Ishizuya-Oka,
Temporal and spatial regulation of a putative transcriptional repressor implicates it as playing a role in thyroid hormone-dependent organ transformation.
1997,
Pubmed
,
Xenbase Ito,
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function.
2001,
Pubmed Jepsen,
Biological roles and mechanistic actions of co-repressor complexes.
2002,
Pubmed Jones,
N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors.
2003,
Pubmed
,
Xenbase Kouzarides,
Chromatin modifications and their function.
2007,
Pubmed Krain,
Developmental expression and hormonal regulation of glucocorticoid and thyroid hormone receptors during metamorphosis in Xenopus laevis.
2004,
Pubmed
,
Xenbase Lachner,
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
2001,
Pubmed Lazar,
Thyroid hormone receptors: multiple forms, multiple possibilities.
1993,
Pubmed Li,
The role of chromatin during transcription.
2007,
Pubmed Mangelsdorf,
The nuclear receptor superfamily: the second decade.
1995,
Pubmed Matsuda,
Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis.
2009,
Pubmed
,
Xenbase Matsuda,
An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development.
2010,
Pubmed
,
Xenbase Maunakea,
Epigenome mapping in normal and disease States.
2010,
Pubmed Nakajima,
Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis.
2003,
Pubmed
,
Xenbase Pasini,
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
2004,
Pubmed Paul,
Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.
2005,
Pubmed
,
Xenbase Paul,
Coactivator recruitment is essential for liganded thyroid hormone receptor to initiate amphibian metamorphosis.
2005,
Pubmed
,
Xenbase Paul,
Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis.
2003,
Pubmed
,
Xenbase Perissi,
Deconstructing repression: evolving models of co-repressor action.
2010,
Pubmed Rachez,
Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.
2000,
Pubmed Rachez,
Mediator complexes and transcription.
2001,
Pubmed Roeder,
Transcriptional regulation and the role of diverse coactivators in animal cells.
2005,
Pubmed Roh,
The genomic landscape of histone modifications in human T cells.
2006,
Pubmed Sato,
A role of unliganded thyroid hormone receptor in postembryonic development in Xenopus laevis.
2007,
Pubmed
,
Xenbase Schreiber,
Remodeling of the intestine during metamorphosis of Xenopus laevis.
2005,
Pubmed
,
Xenbase Schreiber,
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
2001,
Pubmed
,
Xenbase Shi,
Autoactivation of Xenopus Thyroid Hormone Receptor beta Genes Correlates with Larval Epithelial Apoptosis and Adult Cell Proliferation.
1997,
Pubmed
,
Xenbase Shi,
Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes.
2009,
Pubmed
,
Xenbase Shi,
The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis.
2011,
Pubmed
,
Xenbase Shi,
Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis.
1994,
Pubmed
,
Xenbase Shi,
Biphasic intestinal development in amphibians: embryogenesis and remodeling during metamorphosis.
1996,
Pubmed
,
Xenbase Shilatifard,
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.
2006,
Pubmed Sun,
Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis.
2010,
Pubmed
,
Xenbase Tata,
Gene expression during metamorphosis: an ideal model for post-embryonic development.
1993,
Pubmed Tsai,
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
1994,
Pubmed van der Flier,
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
2009,
Pubmed Wang,
Combinatorial patterns of histone acetylations and methylations in the human genome.
2008,
Pubmed Wang,
Characterization of human epigenomes.
2009,
Pubmed Wang,
Developmental regulation and function of thyroid hormone receptors and 9-cis retinoic acid receptors during Xenopus tropicalis metamorphosis.
2008,
Pubmed
,
Xenbase Wong,
Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation.
1997,
Pubmed
,
Xenbase Wong,
Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors.
1995,
Pubmed
,
Xenbase Wong,
A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.
1995,
Pubmed
,
Xenbase Yen,
Physiological and molecular basis of thyroid hormone action.
2001,
Pubmed Zhang,
The mechanism of action of thyroid hormones.
2000,
Pubmed
