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Magenheim J, Ilovich O, Lazarus A, Klochendler A, Ziv O, Werman R, Hija A, Cleaver O, Mishani E, Keshet E, Dor Y.
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How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early development of the liver and pancreas, and are fundamental to normal and pathological tissue growth. Here, we report that, surprisingly, non-nutritional signals from blood vessels act to restrain pancreas growth. Elimination of endothelial cells increases the size of embryonic pancreatic buds. Conversely, VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo, indicating a perfusion-independent mechanism. Thus, the vasculature controls pancreas morphogenesis and growth by reducing branching and differentiation of primitive epithelial cells.
Ahnfelt-Rønne,
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.
2007, Pubmed
Ahnfelt-Rønne,
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.
2007,
Pubmed Ahnfelt-Rønne,
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.
2007,
Pubmed Apelqvist,
Notch signalling controls pancreatic cell differentiation.
1999,
Pubmed
,
Xenbase Butler,
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors.
2010,
Pubmed Butler,
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
2010,
Pubmed D'Amour,
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.
2006,
Pubmed Dor,
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.
2001,
Pubmed Esni,
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.
2004,
Pubmed Gittes,
Developmental biology of the pancreas: a comprehensive review.
2009,
Pubmed Gu,
Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
2004,
Pubmed Hald,
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
2003,
Pubmed Hart,
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
2003,
Pubmed Holland,
Experimental control of pancreatic development and maintenance.
2002,
Pubmed Ilovich,
Formation of fluorine-18 labeled diaryl ureas--labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis.
2008,
Pubmed Jacquemin,
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.
2006,
Pubmed Jørgensen,
An illustrated review of early pancreas development in the mouse.
2007,
Pubmed Kesavan,
Cdc42-mediated tubulogenesis controls cell specification.
2009,
Pubmed Kroon,
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.
2008,
Pubmed Lammert,
Induction of pancreatic differentiation by signals from blood vessels.
2001,
Pubmed
,
Xenbase LeCouter,
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
2003,
Pubmed Magenheim,
Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.
2011,
Pubmed Matsumoto,
Liver organogenesis promoted by endothelial cells prior to vascular function.
2001,
Pubmed May,
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
2008,
Pubmed Murtaugh,
Notch signaling controls multiple steps of pancreatic differentiation.
2003,
Pubmed Murtaugh,
Pancreas and beta-cell development: from the actual to the possible.
2007,
Pubmed Nikolova,
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
2006,
Pubmed Norgaard,
FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.
2003,
Pubmed Oliver-Krasinski,
On the origin of the beta cell.
2008,
Pubmed Palmer,
Vascular niche for adult hippocampal neurogenesis.
2000,
Pubmed Pierreux,
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.
2010,
Pubmed Puri,
Dynamics of embryonic pancreas development using real-time imaging.
2007,
Pubmed Sand,
Growth-limiting role of endothelial cells in endoderm development.
2011,
Pubmed Shalaby,
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis.
1997,
Pubmed Shen,
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells.
2004,
Pubmed Shen,
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.
2008,
Pubmed Solar,
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
2009,
Pubmed Tang,
White fat progenitor cells reside in the adipose vasculature.
2008,
Pubmed Tavazoie,
A specialized vascular niche for adult neural stem cells.
2008,
Pubmed van Eyll,
Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.
2004,
Pubmed Yoshida,
A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis.
2007,
Pubmed Yoshitomi,
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
2004,
Pubmed Zaret,
Pancreatic beta cells: responding to the matrix.
2006,
Pubmed Zaret,
Generation and regeneration of cells of the liver and pancreas.
2008,
Pubmed Zhou,
A multipotent progenitor domain guides pancreatic organogenesis.
2007,
Pubmed
