Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Xenopus laevis is an ideal organism in which to study the mechanisms linking genetics, the embryogenesis of the central nervous system, and the generation of cognitive behavior. Frog embryos facilitate the targeting of many pathways of importance to neuroscience via pharmacological, genetic, and surgical manipulations. A limiting factor for investigations of memory and learning has been the difficulty of eliciting learning in Xenopus. Here, we outline a simple strategy for aversive conditioning (associative learning) in Xenopus tadpoles, and present sample data using a quantitative automated analysis system. We also discuss the factors and variables that must be considered to ensure optimal learning and recall performance, for use as behavioral endpoints in any experiment.
Berghmans,
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
2007, Pubmed
Berghmans,
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
2007,
Pubmed Blackiston,
A second-generation device for automated training and quantitative behavior analyses of molecularly-tractable model organisms.
2010,
Pubmed
,
Xenbase Bretaud,
A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish.
2007,
Pubmed Cahill,
Circadian rhythmicity in the locomotor activity of larval zebrafish.
1998,
Pubmed Darland,
Behavioral screening for cocaine sensitivity in mutagenized zebrafish.
2001,
Pubmed Gerlai,
Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio).
2006,
Pubmed Gerlai,
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects.
2000,
Pubmed Irons,
Acute neuroactive drug exposures alter locomotor activity in larval zebrafish.
2010,
Pubmed López Patiño,
Gender differences in zebrafish responses to cocaine withdrawal.
2008,
Pubmed Pan,
Chronic alcohol exposure induced gene expression changes in the zebrafish brain.
2011,
Pubmed Prober,
Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish.
2006,
Pubmed Zhdanova,
Melatonin promotes sleep-like state in zebrafish.
2001,
Pubmed
