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CLIC proteins are components or regulators of novel intracellular anion channels in mammalian cells, and previous studies have suggested that human nuclear membrane-associated CLIC1 and mouse inner mitochondrial membrane CLIC4 are involved in cell division and apoptosis. We have isolated Xenopus homologues of CLIC1 and CLIC4 and shown them to be well conserved during chordate evolution, but poorly conserved in invertebrates. Consistent with fundamental cellular roles, Xenopus CLIC genes are expressed at every stage of embryonic development. Expression is localised to mesodermal and ectodermal tissues, with particularly marked expression of xCLIC4 in the developing nervous system. This is the first description of non-mammalian CLIC expression, and use of Xenopus laevis as a model organism may provide insights into the role of CLIC-associated ion channels in animal development.
Ashley,
Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review).
2003, Pubmed
Ashley,
Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review).
2003,
Pubmed Berryman,
Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.
2000,
Pubmed Chuang,
A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.
1999,
Pubmed Duncan,
Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum.
1997,
Pubmed Edwards,
A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression.
1999,
Pubmed Fernández-Salas,
mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53.
2002,
Pubmed Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase Harrop,
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
2001,
Pubmed Heiss,
Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.
1997,
Pubmed Howell,
Identification and characterisation of a homologue of p64 in rat tissues.
1996,
Pubmed Jaffe,
Propagating potassium and chloride conductances during activation and fertilization of the egg of the frog, Rana pipiens.
1985,
Pubmed Jentsch,
Molecular structure and physiological function of chloride channels.
2002,
Pubmed Proutski,
Overexpressed chloride intracellular channel protein CLIC4 (p64H1) is an essential component of novel plasma membrane anion channels.
2002,
Pubmed Qian,
Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
1999,
Pubmed Rønnov-Jessen,
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts.
2002,
Pubmed Shanks,
AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.
2002,
Pubmed Suginta,
Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms.
2001,
Pubmed Tonini,
Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells.
2000,
Pubmed Valenzuela,
Molecular cloning and expression of a chloride ion channel of cell nuclei.
1997,
Pubmed Valenzuela,
The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.
2000,
Pubmed
