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Cell
2013 Feb 14;1524:669-70. doi: 10.1016/j.cell.2013.01.040.
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Nucleating new branches from old.
Zheng Y, Iglesias PA.
???displayArticle.abstract??? Centrosome- and chromatin-based microtubule nucleation pathways have been implicated in spindle assembly. Using total internal reflection fluorescent microscopy and Xenopus egg extracts, Petry et al. demonstrate that new microtubules can also nucleate and branch out from existing ones in animal cells.
Clausen,
Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient.
2007, Pubmed,
Xenbase
Clausen,
Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient.
2007,
Pubmed
,
Xenbase Goshima,
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.
2008,
Pubmed Gruss,
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.
2001,
Pubmed
,
Xenbase Kalab,
Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts.
2002,
Pubmed
,
Xenbase Li,
Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.
2004,
Pubmed
,
Xenbase Loughlin,
A computational model predicts Xenopus meiotic spindle organization.
2010,
Pubmed
,
Xenbase Petry,
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.
2013,
Pubmed
,
Xenbase Tsai,
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.
2003,
Pubmed
,
Xenbase Wollman,
Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly.
2005,
Pubmed Zheng,
Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex.
1995,
Pubmed
,
Xenbase
