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J Innate Immun
2013 Jan 01;56:531-42. doi: 10.1159/000346928.
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Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver.
???displayArticle.abstract??? Macrophage precursors originate from and undergo lineage commitment within designated sites of hematopoiesis, such as the mammalian bone marrow. These cells subsequently differentiate in response to stimulation with macrophage colony-stimulating factor-1 (CSF-1). The amphibian bone marrow, unlike that of mammals, has been overlooked as a source of leukocyte precursors in favor of the liver subcapsular region, where hematopoiesis occurs in anurans. Here we report that the bone marrow rather than the liver periphery provides macrophage progenitors to the amphibian Xenopus laevis. We identified the amphibian CSF-1, examined its gene expression in developing and virally infected X. lae vis and produced it in recombinant form (rXlCSF-1). This rXlCSF-1 did not bind or elicit proliferation/differentiation of subcapsular liver cells. Surprisingly, a subpopulation of bone marrow cells engaged this growth factor and formed rXlCSF-1 concentration-dependent colonies in semisolid medium. Furthermore, rXlCSF-1-treated bone marrow (but not liver) cultures comprised of cells with characteristic macrophage morphology and high gene expression of the macrophage marker CSF-1 receptor. Together, our findings indicate that in contrast to all other vertebrates studied to date, committed Xenopus macrophage precursor populations are not present at the central site of hematopoiesis, but reside in the bone marrow.
Amemiya,
Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy: the role of M-CSF-induced macrophages.
2011, Pubmed
Amemiya,
Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy: the role of M-CSF-induced macrophages.
2011,
Pubmed Bakheet,
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins.
2001,
Pubmed Bartelmez,
Interleukin 1 plus interleukin 3 plus colony-stimulating factor 1 are essential for clonal proliferation of primitive myeloid bone marrow cells.
1989,
Pubmed Belosevic,
Development of goldfish macrophages in vitro.
2006,
Pubmed Bhatnagar,
CSF-1 and mouse preimplantation development in vitro.
1995,
Pubmed Bonifer,
The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis.
2008,
Pubmed Carver,
Studies of the development of frog hemopoietic tissue in vitro. I. Spleen culture assay of an erythropoietic factor in anemic frog blood.
1977,
Pubmed Cecchini,
Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse.
1994,
Pubmed Chen,
Intraembryonic origin of hepatic hematopoiesis in Xenopus laevis.
1995,
Pubmed
,
Xenbase Dai,
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects.
2002,
Pubmed Flajnik,
Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules.
1990,
Pubmed
,
Xenbase Garceau,
Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products.
2010,
Pubmed Guilbert,
Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells.
1980,
Pubmed Hadji-Azimi,
B-lymphocyte populations in Xenopus laevis.
1990,
Pubmed
,
Xenbase Hadji-Azimi,
Atlas of adult Xenopus laevis laevis hematology.
1987,
Pubmed
,
Xenbase Hanington,
Growth factors of lower vertebrates: characterization of goldfish (Carassius auratus L.) macrophage colony-stimulating factor-1.
2007,
Pubmed Kawasaki,
Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).
1985,
Pubmed Koths,
Structure-function studies on human macrophage colony-stimulating factor (M-CSF).
1997,
Pubmed Kriegler,
The relationship between different high proliferative potential colony-forming cells in mouse bone marrow.
1994,
Pubmed Krysinska,
A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.
2007,
Pubmed Lane,
Primitive and definitive blood share a common origin in Xenopus: a comparison of lineage techniques used to construct fate maps.
2002,
Pubmed
,
Xenbase Lichanska,
Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.
1999,
Pubmed Lin,
Both granulocyte-macrophage CSF and macrophage CSF control the proliferation and survival of the same subset of alveolar macrophages.
1989,
Pubmed Manos,
Expression and processing of a recombinant human macrophage colony-stimulating factor in mouse cells.
1988,
Pubmed Morales,
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
2010,
Pubmed
,
Xenbase Neumann,
Generation and functional analysis of distinct macrophage sub-populations from goldfish (Carassius auratus L.) kidney leukocyte cultures.
2000,
Pubmed Nishikawa,
Roles of macrophages in programmed cell death and remodeling of tail and body muscle of Xenopus laevis during metamorphosis.
1998,
Pubmed
,
Xenbase Nogawa-Kosaka,
Identification of erythroid progenitors induced by erythropoietic activity in Xenopus laevis.
2011,
Pubmed
,
Xenbase Pixley,
CSF-1 regulation of the wandering macrophage: complexity in action.
2004,
Pubmed Rettenmier,
Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.
1988,
Pubmed Robert,
Xenopus laevis: a possible vector of Ranavirus infection?
2007,
Pubmed
,
Xenbase Rosa,
The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation.
2007,
Pubmed Sasmono,
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
2007,
Pubmed Stanley,
Induction of macrophage production and proliferation by a purified colony stimulating factor.
1978,
Pubmed Tagoh,
Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.
2002,
Pubmed Taylor,
Structure-function studies on recombinant human macrophage colony-stimulating factor (M-CSF).
1994,
Pubmed Tushinski,
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.
1982,
Pubmed Wang,
Two macrophage colony-stimulating factor genes exist in fish that differ in gene organization and are differentially expressed.
2008,
Pubmed
