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Immunogenetics
2014 Jun 01;666:411-26. doi: 10.1007/s00251-014-0774-5.
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Unusual evolutionary conservation and further species-specific adaptations of a large family of nonclassical MHC class Ib genes across different degrees of genome ploidy in the amphibian subfamily Xenopodinae.
Edholm ES, Goyos A, Taran J, De Jesús Andino F, Ohta Y, Robert J.
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Nonclassical MHC class Ib (class Ib) genes are a family of highly diverse and rapidly evolving genes wherein gene numbers, organization, and expression markedly differ even among closely related species rendering class Ib phylogeny difficult to establish. Whereas among mammals there are few unambiguous class Ib gene orthologs, different amphibian species belonging to the anuran subfamily Xenopodinae exhibit an unusually high degree of conservation among multiple class Ib gene lineages. Comparative genomic analysis of class Ib gene loci of two divergent (~65 million years) Xenopodinae subfamily members Xenopus laevis (allotetraploid) and Xenopus tropicalis (diploid) shows that both species possess a large cluster of class Ib genes denoted as Xenopus/Silurana nonclassical (XNC/SNC). Our study reveals two distinct phylogenetic patterns among these genes: some gene lineages display a high degree of flexibility, as demonstrated by species-specific expansion and contractions, whereas other class Ib gene lineages have been maintained as monogenic subfamilies with very few changes in their nucleotide sequence across divergent species. In this second category, we further investigated the XNC/SNC10 gene lineage that in X. laevis is required for the development of a distinct semi-invariant T cell population. We report compelling evidence of the remarkable high degree of conservation of this gene lineage that is present in all 12 species of the Xenopodinae examined, including species with different degrees of ploidy ranging from 2, 4, 8 to 12 N. This suggests that the critical role of XNC10 during early T cell development is conserved in amphibians.
Adams,
Species-specific evolution of MHC class I genes in the higher primates.
2001, Pubmed
Adams,
Species-specific evolution of MHC class I genes in the higher primates.
2001,
Pubmed Adams,
The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
2013,
Pubmed Baker,
Evolution of mammalian CD1: marsupial CD1 is not orthologous to the eutherian isoforms and is a pseudogene in the opossum Monodelphis domestica.
2007,
Pubmed Bartl,
Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response.
1997,
Pubmed Beckman,
Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.
1994,
Pubmed Bendelac,
CD1 recognition by mouse NK1+ T lymphocytes.
1995,
Pubmed Bendelac,
The biology of NKT cells.
2007,
Pubmed Bewick,
The pipid root.
2012,
Pubmed
,
Xenbase Bjorkman,
Structure of the human class I histocompatibility antigen, HLA-A2.
,
Pubmed Brigl,
CD1: antigen presentation and T cell function.
2004,
Pubmed Chida,
Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevis.
2011,
Pubmed
,
Xenbase Dascher,
Evolutionary biology of CD1.
2007,
Pubmed Dijkstra,
A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes.
2007,
Pubmed Edholm,
Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians.
2013,
Pubmed
,
Xenbase Evans,
A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution.
2004,
Pubmed
,
Xenbase Evans,
Genome evolution and speciation genetics of clawed frogs (Xenopus and Silurana).
2008,
Pubmed
,
Xenbase Flajnik,
A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus.
1993,
Pubmed
,
Xenbase Flajnik,
Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis.
1986,
Pubmed
,
Xenbase Flajnik,
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system.
2001,
Pubmed Goyos,
Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species.
2011,
Pubmed
,
Xenbase Goyos,
Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors.
2009,
Pubmed
,
Xenbase Hansen,
Patterns of nonclassical MHC antigen presentation.
2007,
Pubmed Hellsten,
The genome of the Western clawed frog Xenopus tropicalis.
2010,
Pubmed
,
Xenbase Joly,
The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules.
2006,
Pubmed Kasahara,
Evolution of the major histocompatibility complex: a current overview.
1995,
Pubmed Kronenberg,
The unconventional lifestyle of NKT cells.
2002,
Pubmed Kulski,
Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man.
2002,
Pubmed Le Bourhis,
Antimicrobial activity of mucosal-associated invariant T cells.
2010,
Pubmed Le Bourhis,
Mucosal-associated invariant T cells: unconventional development and function.
2011,
Pubmed Lukacs,
Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.
2010,
Pubmed Matsuda,
Developmental program of mouse Valpha14i NKT cells.
2005,
Pubmed Miller,
Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
2005,
Pubmed Nei,
Concerted and birth-and-death evolution of multigene families.
2005,
Pubmed Nei,
Evolution by the birth-and-death process in multigene families of the vertebrate immune system.
1997,
Pubmed Patel,
Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
2013,
Pubmed Piontkivska,
Birth-and-death evolution in primate MHC class I genes: divergence time estimates.
2003,
Pubmed Robert,
Comparative and developmental study of the immune system in Xenopus.
2009,
Pubmed
,
Xenbase Rodgers,
MHC class Ib molecules bridge innate and acquired immunity.
2005,
Pubmed Rollins-Smith,
Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.
1997,
Pubmed
,
Xenbase Salter-Cid,
Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes.
1998,
Pubmed
,
Xenbase Sammut,
Axolotl MHC architecture and polymorphism.
1999,
Pubmed
,
Xenbase Saper,
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution.
1991,
Pubmed Sköld,
Role of CD1d-restricted NKT cells in microbial immunity.
2003,
Pubmed Star,
The genome sequence of Atlantic cod reveals a unique immune system.
2011,
Pubmed Tamura,
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.
2011,
Pubmed Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed Treiner,
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1.
2003,
Pubmed Tsukamoto,
Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals.
2013,
Pubmed Wang,
Characterization of a divergent non-classical MHC class I gene in sharks.
2003,
Pubmed
