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Figure 2. Nuclear coexpression of IQGAP1 and Dvl is correlated with cyclin D1 and c-myc expression.Coexpression of IQGAP1 (A) and Dvl (C) in the nucleus of lung adenocarcinoma. Coexpression of IQGAP1 (B) and Dvl (D) in the nucleus of lung squamous cell carcinoma. Positive expression of cyclin D1 (E) and c-myc (G) in lung adenocarcinoma. Positive expression of cyclin D1 (F) and c-myc (H) in lung squamous cell carcinoma. Original magnification, 400×; scale bar, 20 µm.
Figure 3. Kaplan–Meier analysis showing overall survival among NSCLC patients.(A) a.the group with IQGAP1 and Dvl noncoexpression in the cytoplasm and nucleus (61 cases); b.the group with IQGAP1 and Dvl coexpression in the cytoplasm and nucleus (50 cases) (B) a.the group with IQGAP1 and Dvl noncoexpression in the cytoplasm and nucleus (61 cases); b.the group with IQGAP1 and Dvl coexpression in the cytoplasm (42 cases); c.the group with IQGAP1 and Dvl coexpression in the nucleus (8 cases).
Figure 1. Coexpression of IQGAP1 (A, C) and Dvl (B, D) in the cytoplasm of NSCLC.A–B: adenocarcinoma; C–D: squamous cell carcinoma. Original magnification, 400×; scale bar, 20 µm.
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Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.
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