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Tiki1 is a Wnt protease and antagonist specifically expressed in the Spemann-Mangold Organizer and is required for head formation in Xenopus embryos. Here we report neighbor-joining phylogenetic analysis of vertebrate Tiki genes and their mRNA expression patterns in chick, mouse, and rabbit embryos. Tiki1 and Tiki2 orthologues are highly conserved, and exhibit similar but also different developmental expression patterns among the vertebrate/mammalian species analyzed. The Tiki1 gene is noticeably absent in the rodent lineage, but is present in lagomorphs and all other vertebrate/mammalian species examined. Expression in Hensen's node, the equivalent of the Xenopus Organizer, was observed for Chick Tiki2 and Rabbit Tiki1 and Tiki2. Mouse Tiki2 was detected at low levels at gastrulation and head fold stages, but not in the node. Mouse Tiki2 and chick Tiki1 display similar expression in the dorsal spinal cord. Chick Tiki1 expression was also detected in the surface ectoderm and maxillary bud, while chick Tiki2 was found in the anterior intestinal portal, head mesenchyme and primitive atrium. Our expression analyses provide evidence that Tiki1 and Tiki2 are evolutionarily conserved among vertebrate species and their expression in the Organizer and other regions suggests contributions of these Wnt inhibitors to embryonic patterning, as well as organogenesis. Our analyses further reveal mis-regulation of TIKI1 and TIKI2 in human cancer and diseases.
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25354456 ???displayArticle.pmcLink???PMC4528638 ???displayArticle.link???Int J Dev Biol ???displayArticle.grants???[+]
Adamska,
Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb.
2003, Pubmed
Adamska,
Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb.
2003,
Pubmed Arkell,
Initiating head development in mouse embryos: integrating signalling and transcriptional activity.
2012,
Pubmed Bafico,
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.
2001,
Pubmed Baron,
WNT signaling in bone homeostasis and disease: from human mutations to treatments.
2013,
Pubmed Barrett,
NCBI GEO: archive for functional genomics data sets--update.
2013,
Pubmed Bazan,
The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?
2013,
Pubmed Belo,
Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family.
2009,
Pubmed
,
Xenbase Benton,
Paleontological evidence to date the tree of life.
2007,
Pubmed Blum,
Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo.
2007,
Pubmed
,
Xenbase Brito,
Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells.
2008,
Pubmed Clevers,
Wnt/β-catenin signaling and disease.
2012,
Pubmed Cruciat,
Secreted and transmembrane wnt inhibitors and activators.
2013,
Pubmed
,
Xenbase De Robertis,
Dorsal-ventral patterning and neural induction in Xenopus embryos.
2004,
Pubmed
,
Xenbase Fischer,
FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit.
2002,
Pubmed Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
,
Xenbase HAMBURGER,
A series of normal stages in the development of the chick embryo.
1951,
Pubmed Idkowiak,
Polarity in the rabbit embryo.
2004,
Pubmed Kuroda,
Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.
2004,
Pubmed
,
Xenbase Li,
TIKI2 suppresses growth of osteosarcoma by targeting Wnt/β-catenin pathway.
2014,
Pubmed MacDonald,
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
2009,
Pubmed
,
Xenbase Mao,
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
2001,
Pubmed
,
Xenbase Marvin,
Inhibition of Wnt activity induces heart formation from posterior mesoderm.
2001,
Pubmed
,
Xenbase Niehrs,
Regionally specific induction by the Spemann-Mangold organizer.
2004,
Pubmed Parkinson,
ArrayExpress update--an archive of microarray and high-throughput sequencing-based functional genomics experiments.
2011,
Pubmed Petersen,
Wnt signaling and the polarity of the primary body axis.
2009,
Pubmed Piccaluga,
Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation.
2007,
Pubmed Rhodes,
Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles.
2007,
Pubmed Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed Sanchez-Pulido,
Tiki, at the head of a new superfamily of enzymes.
2013,
Pubmed Semënov,
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
2001,
Pubmed
,
Xenbase Solnica-Krezel,
Gastrulation: making and shaping germ layers.
2012,
Pubmed Viebahn,
The anterior margin of the mammalian gastrula: comparative and phylogenetic aspects of its role in axis formation and head induction.
1999,
Pubmed Xavier-Neto,
Retinoid signaling and cardiac anteroposterior segmentation.
2001,
Pubmed Zhang,
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
2012,
Pubmed
,
Xenbase Zhang,
Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues.
2012,
Pubmed
