Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The epithelial lining of the respiratory system originates from a small group of progenitor cells in the ventralforegut endoderm of the early embryo. Research in the last decade has revealed a number of paracrine signaling pathways that are critical for the development of these respiratory progenitors. In the post-genomic era the challenge now is to figure out at the genome wide level how these different signaling pathways and their downstream transcription factors interact in a complex "gene regulatory network" (GRN) to orchestrate early lung development. In this prospective, we review our growing understanding of the GRN governing lung specification. We discuss key gaps in our knowledge and describe emerging opportunities that will soon provide an unprecedented understanding of lung development and accelerate our ability to apply this knowledge to regenerative medicine.
Arda,
Gene regulatory networks governing pancreas development.
2013,
Pubmed Arora,
Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system.
2012,
Pubmed Aubin,
Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects.
1997,
Pubmed Beers,
The three R's of lung health and disease: repair, remodeling, and regeneration.
2011,
Pubmed Burgess,
Technology: a CRISPR genome-editing tool.
2013,
Pubmed Chen,
A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium.
2010,
Pubmed Chen,
Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction.
2007,
Pubmed Domyan,
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.
2011,
Pubmed ENCODE Project Consortium,
An integrated encyclopedia of DNA elements in the human genome.
2012,
Pubmed Fagman,
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning.
2011,
Pubmed Goss,
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.
2009,
Pubmed Guazzi,
The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.
1994,
Pubmed
,
Xenbase Harris-Johnson,
beta-Catenin promotes respiratory progenitor identity in mouse foregut.
2009,
Pubmed Herriges,
Lung development: orchestrating the generation and regeneration of a complex organ.
2014,
Pubmed Huang,
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
2014,
Pubmed Ikeda,
Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells.
1996,
Pubmed Jaitin,
Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types.
2014,
Pubmed Kieffer-Kwon,
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
2013,
Pubmed Kim,
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs.
2011,
Pubmed Lazzaro,
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.
1991,
Pubmed Li,
Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.
2008,
Pubmed Litingtung,
Sonic hedgehog is essential to foregut development.
1998,
Pubmed
,
Xenbase Longmire,
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells.
2012,
Pubmed Millien,
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
2008,
Pubmed Min,
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.
1998,
Pubmed Minoo,
Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.
1999,
Pubmed Mitra,
Integrative approaches for finding modular structure in biological networks.
2013,
Pubmed Motoyama,
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.
1998,
Pubmed
,
Xenbase Mou,
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs.
2012,
Pubmed Packer,
Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning.
2000,
Pubmed Peng,
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.
2013,
Pubmed Peter,
Predictive computation of genomic logic processing functions in embryonic development.
2012,
Pubmed Que,
Multiple roles for Sox2 in the developing and adult mouse trachea.
2009,
Pubmed Que,
Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps.
2006,
Pubmed Rankin,
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
2012,
Pubmed
,
Xenbase Robbins,
The Hedgehog signal transduction network.
2012,
Pubmed Ryckebusch,
Retinoic acid deficiency alters second heart field formation.
2008,
Pubmed Sakiyama,
Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development.
2003,
Pubmed Sekine,
Fgf10 is essential for limb and lung formation.
1999,
Pubmed Serls,
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung.
2005,
Pubmed Shifley,
Prolonged FGF signaling is necessary for lung and liver induction in Xenopus.
2012,
Pubmed
,
Xenbase Spilde,
A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula.
2003,
Pubmed Tian,
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
2010,
Pubmed Tian,
Regulation of lung endoderm progenitor cell behavior by miR302/367.
2011,
Pubmed Volckaert,
Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.
2013,
Pubmed Wan,
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
2005,
Pubmed Wang,
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
2006,
Pubmed Wang,
Retinoic acid is a key regulatory switch determining the difference between lung and thyroid fates in Xenopus laevis.
2011,
Pubmed
,
Xenbase Wang,
Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway.
2013,
Pubmed Whitsett,
Intersections between pulmonary development and disease.
2011,
Pubmed Wong,
Generation of Lung Epithelium from Pluripotent Stem Cells.
2013,
Pubmed Xie,
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
2013,
Pubmed Yin,
An FGF-WNT gene regulatory network controls lung mesenchyme development.
2008,
Pubmed Zaret,
Pioneer transcription factors: establishing competence for gene expression.
2011,
Pubmed Zorn,
Vertebrate endoderm development and organ formation.
2009,
Pubmed
,
Xenbase
