Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
A rise in intracellular Ca2+ (Ca2+i) mediates various cellular functions ranging from fertilization to gene expression. A ubiquitous Ca2+ influx pathway that contributes significantly to the generation of Ca2+i signals, especially in non-excitable cells, is store-operated Ca2+ entry (SOCE). Consequently, the modulation of SOCE current affects Ca2+i dynamics and thus the ensuing cellular response. Therefore, it is important to define the mechanisms that regulate SOCE. Here we show that a rise in Ca2+i potentiates SOCE. This potentiation is mediated by Ca2+-calmodulin-dependent protein kinase II (CaMKII), because inhibition of endogenous CaMKII activity abrogates Ca2+i-mediated SOCE potentiation and expression of constitutively active CaMKII potentiates SOCE current independently of Ca2+i. Moreover, we present evidence that CaMKII potentiates SOCE by altering SOCE channel gating. The regulation of SOCE by CaMKII defines a novel modulatory mechanism of SOCE with important physiological consequences.
Barrett,
Stimulation of unitary T-type Ca(2+) channel currents by calmodulin-dependent protein kinase II.
2000, Pubmed
Barrett,
Stimulation of unitary T-type Ca(2+) channel currents by calmodulin-dependent protein kinase II.
2000,
Pubmed Christian,
Calcium-dependent enhancement of depletion-activated calcium current in Jurkat T lymphocytes.
1996,
Pubmed De Koninck,
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.
1998,
Pubmed Dzhura,
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.
2000,
Pubmed Fanger,
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
1995,
Pubmed Fomina,
A current activated on depletion of intracellular Ca2+ stores can regulate exocytosis in adrenal chromaffin cells.
1999,
Pubmed Gailly,
Role of [Ca2+]i in "Ca2+ stores depletion-Ca2+ entry coupling' in fibroblasts expressing the rat neurotensin receptor.
1996,
Pubmed Hanson,
Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.
1994,
Pubmed Hartzell,
Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.
1996,
Pubmed
,
Xenbase Hook,
Ca(2+)/CaM-dependent kinases: from activation to function.
2001,
Pubmed Hoth,
Calcium release-activated calcium current in rat mast cells.
1993,
Pubmed Hoth,
Depletion of intracellular calcium stores activates a calcium current in mast cells.
1992,
Pubmed Hudmon,
Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.
2002,
Pubmed Ishida,
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
1995,
Pubmed Kuruma,
Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals.
2000,
Pubmed
,
Xenbase Lewis,
Store-operated calcium channels.
1999,
Pubmed Machaca,
Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca(2+) store depletion from store-operated Ca(2+) entry.
2002,
Pubmed
,
Xenbase Machaca,
Store-operated calcium entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis.
2000,
Pubmed
,
Xenbase Machaca,
Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.
1999,
Pubmed
,
Xenbase Matifat,
Involvement of the Ca2+/calmodulin-dependent protein kinase II pathway in the Ca2+-mediated regulation of the capacitative Ca2+ entry in Xenopus oocytes.
1997,
Pubmed
,
Xenbase McCarron,
Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II.
1992,
Pubmed Norwood,
Store-operated calcium entry and increased endothelial cell permeability.
2000,
Pubmed O'Toole,
Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction.
2000,
Pubmed Parekh,
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.
1995,
Pubmed Parekh,
The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release.
1997,
Pubmed Parekh,
Store depletion and calcium influx.
1997,
Pubmed Parekh,
Ca2+ oscillations and Ca2+ influx in Xenopus oocytes expressing a novel 5-hydroxytryptamine receptor.
1993,
Pubmed
,
Xenbase Petersen,
The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes.
1994,
Pubmed
,
Xenbase Quick,
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.
1994,
Pubmed
,
Xenbase Serafini,
Isolation of mutant T lymphocytes with defects in capacitative calcium entry.
1995,
Pubmed Shen,
Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.
1999,
Pubmed Srinivasan,
Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.
1994,
Pubmed Stevens,
Cloning and differential expression of new calcium, calmodulin-dependent protein kinase II isoforms in Xenopus laevis oocytes and several adult tissues.
2001,
Pubmed
,
Xenbase Vazquez,
Involvement of calmodulin in 1alpha,25-dihydroxyvitamin D3 stimulation of store-operated Ca2+ influx in skeletal muscle cells.
2000,
Pubmed Waldmann,
Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies.
1990,
Pubmed
,
Xenbase Yao,
Calcium current activated by depletion of calcium stores in Xenopus oocytes.
1997,
Pubmed
,
Xenbase Zweifach,
Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.
1995,
Pubmed Zweifach,
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.
1995,
Pubmed Zweifach,
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
1996,
Pubmed
