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Genome Res
2003 Jun 01;136A:1082-96. doi: 10.1101/gr.479603.
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The zebrafish annexin gene family.
Farber SA, De Rose RA, Olson ES, Halpern ME.
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The Annexins (ANXs) are a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity. As a first step toward understanding in vivo function, we have cloned 11 zebrafish anx genes. Four genes (anx1a, anx2a, anx5,and anx11a) were identified by screening a zebrafish cDNA library with a Xenopus anx2 fragment. For these genes, full-length cDNA sequences were used to cluster 212 EST sequences generated by the Zebrafish Genome Resources Project. The EST analysis revealed seven additional anx genes that were subsequently cloned. The genetic map positions of all 11 genes were determined by using a zebrafish radiation hybrid panel. Sequence and syntenic relationships between zebrafish and human genes indicate that the 11 genes represent orthologs of human anx1,2,4,5,6,11,13,and suggest that several zebrafish anx genes resulted from duplications that arose after divergence of the zebrafish and mammalian genomes. Zebrafish anx genes are expressed in a wide range of tissues during embryonic and larval stages. Analysis of the expression patterns of duplicated genes revealed both redundancy and divergence, with the most similar genes having almost identical tissue-specific patterns of expression and with less similar duplicates showing no overlap. The differences in gene expression of recently duplicated anx genes could explain why highly related paralogs were maintained in the genome and did not rapidly become pseudogenes.
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12799347 ???displayArticle.pmcLink???PMC403637 ???displayArticle.link???Genome Res
Altschul,
Issues in searching molecular sequence databases.
1994, Pubmed
Altschul,
Issues in searching molecular sequence databases.
1994,
Pubmed Amores,
Zebrafish hox clusters and vertebrate genome evolution.
1998,
Pubmed Aparicio,
Exploding vertebrate genomes.
1998,
Pubmed Bandorowicz-Pikuła,
Annexins and ATP in membrane traffic: a comparison with membrane fusion machinery.
1998,
Pubmed Bastian,
Localization of annexins in normal and diseased human skin.
1993,
Pubmed Bonfils,
Expression and characterization of a Dictyostelium discoideum annexin.
1994,
Pubmed Brugge,
The p35/p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2.
1986,
Pubmed Creutz,
Identification, localization, and functional implications of an abundant nematode annexin.
1996,
Pubmed Creutz,
cis-Unsaturated fatty acids induce the fusion of chromaffin granules aggregated by synexin.
1981,
Pubmed Croxtal,
The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1beta in A549 cells.
1996,
Pubmed Davidson,
Binding and inhibition studies on lipocortins using phosphatidylcholine vesicles and phospholipase A2 from snake venom, pancreas, and a macrophage-like cell line.
1990,
Pubmed Davidson,
Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.
1987,
Pubmed de Coupade,
Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice.
2000,
Pubmed Donnelly,
Annexins in the secretory pathway.
1997,
Pubmed Dreier,
Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study.
1998,
Pubmed Drummond,
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.
1998,
Pubmed Emans,
Annexin II is a major component of fusogenic endosomal vesicles.
1993,
Pubmed Fiedler,
Annexin homologues in Giardia lamblia.
1995,
Pubmed Force,
Preservation of duplicate genes by complementary, degenerative mutations.
1999,
Pubmed Frohman,
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.
1988,
Pubmed Gerke,
Annexins and membrane dynamics.
1997,
Pubmed Glenney,
Phosphorylation of p36 in vitro with pp60src. Regulation by Ca2+ and phospholipid.
1985,
Pubmed Halpern,
Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation.
1993,
Pubmed Herbomel,
Ontogeny and behaviour of early macrophages in the zebrafish embryo.
1999,
Pubmed Huang,
Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.
1986,
Pubmed Hukriede,
Radiation hybrid mapping of the zebrafish genome.
1999,
Pubmed Johnston,
Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development.
1990,
Pubmed Kaetzel,
A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance.
1994,
Pubmed Kim,
Annexin-I inhibits phospholipase A2 by specific interaction, not by substrate depletion.
1994,
Pubmed Kimmel,
Stages of embryonic development of the zebrafish.
1995,
Pubmed
,
Xenbase Kobayashi,
Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic.
1998,
Pubmed König,
The annexin II-p11 complex is involved in regulated exocytosis in bovine pulmonary artery endothelial cells.
1998,
Pubmed Ma,
Annexins I and II show differences in subcellular localization and differentiation-related changes in human epidermal keratinocytes.
1996,
Pubmed Massey-Harroche,
Polarized localizations of annexins I, II, VI and XIII in epithelial cells of intestinal, hepatic and pancreatic tissues.
1998,
Pubmed Meyer,
Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions.
1999,
Pubmed Minin,
Protein kinase C and casein kinase 2 phosphorylate in vitro proteins of the annexin family from eggs of loach Misgurnus fossilis.
1998,
Pubmed Mira,
Inhibition of cytosolic phospholipase A2 by annexin V in differentiated permeabilized HL-60 cells. Evidence of crucial importance of domain I type II Ca2+-binding site in the mechanism of inhibition.
1997,
Pubmed Morgan,
Annexin gene structures and molecular evolutionary genetics.
1997,
Pubmed Morgan,
Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution.
1999,
Pubmed Morgan,
Distinct annexin subfamilies in plants and protists diverged prior to animal annexins and from a common ancestor.
1997,
Pubmed Munz,
Differential expression of the calpactin I subunits annexin II and p11 in cultured keratinocytes and during wound repair.
1997,
Pubmed Nasevicius,
Effective targeted gene 'knockdown' in zebrafish.
2000,
Pubmed Nilius,
Annexin II modulates volume-activated chloride currents in vascular endothelial cells.
1996,
Pubmed Osterloh,
Characterization and developmentally regulated expression of four annexins in the killifish medaka.
1998,
Pubmed Postlethwait,
The zebrafish genome.
1999,
Pubmed Postlethwait,
Vertebrate genome evolution and the zebrafish gene map.
1998,
Pubmed Prince,
Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk.
1998,
Pubmed Rajarao,
The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio.
2001,
Pubmed Raynor,
Annexin II enhances cytomegalovirus binding and fusion to phospholipid membranes.
1999,
Pubmed Sagerström,
Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions.
1996,
Pubmed Schlaepfer,
Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII.
1992,
Pubmed Schmitz-Peiffer,
Activated protein kinase C alpha associates with annexin VI from skeletal muscle.
1998,
Pubmed Smallwood,
Purification and partial sequence analysis of plant annexins.
1990,
Pubmed Smallwood,
Characterization of plant annexin gene expression.
1990,
Pubmed Smith,
Structural evolution of the annexin supergene family.
1994,
Pubmed Thisse,
Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos.
1993,
Pubmed Tokumitsu,
A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family.
1992,
Pubmed Wagner,
The role of population size, pleiotropy and fitness effects of mutations in the evolution of overlapping gene functions.
2000,
Pubmed Weinberg,
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos.
1996,
Pubmed
