Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Biol Sci
2015 Dec 07;2821820:20152201. doi: 10.1098/rspb.2015.2201.
Show Gene links
Show Anatomy links
Nucleolar dominance and maternal control of 45S rDNA expression.
Michalak K, Maciak S, Kim YB, Santopietro G, Oh JH, Kang L, Garner HR, Michalak P.
???displayArticle.abstract???
Using a system of interspecies hybrids, trihybrids, and recombinants with varying proportions of genomes from three distinct Xenopus species, we provide evidence for de novo epigenetic silencing of paternal 45 S ribosomal ribonucleic acid (rRNA) genes and their species-dependent expression dominance that escapes transcriptional inactivation after homologous recombination. The same pattern of imprinting is maintained in the offspring from mothers being genetic males (ZZ) sex-reversed to females, indicating that maternal control of ribosomal deoxyribonucleic acid (rDNA) expression is not sex-chromosome linked. Nucleolar dominance (nucleolus underdevelopment) in Xenopus hybrids appears to be associated with a major non-Mendelian reduction in the number of 45 S rDNA gene copies rather than a specific pattern of their expression. The loss of rRNA gene copies in F1 hybrids was non-random with respect to the parental species, with the transcriptionally dominant variant preferentially removed from hybrid zygotes. This dramatic disruption in the structure and function of 45 S rDNA impacts transcriptome patterns of small nucleolar RNAs and messenger RNAs, with genes from the ribosome and oxidative stress pathways being among the most affected. Unorthodoxies of rDNA inheritance and expression may be interpreted as hallmarks of genetic conflicts between parental genomes, as well as defensive epigenetic mechanisms employed to restore genome integrity.
Bach,
Sequence organization of the spacer in the ribosomal genes of Xenopus clivii and Xenopus borealis.
1981, Pubmed,
Xenbase
Bach,
Sequence organization of the spacer in the ribosomal genes of Xenopus clivii and Xenopus borealis.
1981,
Pubmed
,
Xenbase Blackler,
Transmission of sex cells of one species through the body of a second species in the genus Xenopus. II. Interspecific matings.
1972,
Pubmed
,
Xenbase Boisvert,
The multifunctional nucleolus.
2007,
Pubmed Brown,
A comparison of the ribosomal DNA's of Xenopus laevis and Xenopus mulleri: the evolution of tandem genes.
1972,
Pubmed
,
Xenbase Burton,
A disproportionate role for mtDNA in Dobzhansky-Muller incompatibilities?
2012,
Pubmed Carmo-Fonseca,
To be or not to be in the nucleolus.
2000,
Pubmed Cassidy,
Repression of nucleolar organizer activity in an interspecific hybrid of the genus Xenopus.
1974,
Pubmed
,
Xenbase Caudy,
Xenopus ribosomal RNA gene intergenic spacer elements conferring transcriptional enhancement and nucleolar dominance-like competition in oocytes.
2002,
Pubmed
,
Xenbase Cavaillé,
Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region.
2002,
Pubmed Chen,
Transcriptional analysis of nucleolar dominance in polyploid plants: biased expression/silencing of progenitor rRNA genes is developmentally regulated in Brassica.
1997,
Pubmed D'Amours,
Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.
2004,
Pubmed Delany,
Teratogenic development in chicken embryos associated with a major deletion in the rRNA gene cluster.
1995,
Pubmed Delany,
Formation of nucleolar polymorphisms in trisomic chickens and subsequent microevolution of rRNA gene clusters in diploids.
1991,
Pubmed Donald,
Ribosomal RNA genes and the B chromosome of Brachycome dichromosomatica.
1995,
Pubmed Eagle,
Copy number variation of ribosomal DNA and Pokey transposons in natural populations of Daphnia.
2012,
Pubmed Eickbush,
Retrotransposition of R2 elements in somatic nuclei during the early development of Drosophila.
2011,
Pubmed Etter,
Ribosomal heterogeneity from chromatin diminution in Ascaris lumbricoides.
1994,
Pubmed Fox,
Origin and evolution of the ribosome.
2010,
Pubmed Furlong,
Patterns of major divergence between the internal transcribed spacers of ribosomal DNA in Xenopus borealis and Xenopus laevis, and of minimal divergence within ribosomal coding regions.
1983,
Pubmed
,
Xenbase Graves,
Mammals that break the rules: genetics of marsupials and monotremes.
1996,
Pubmed Gurdon,
Nuclear reprogramming in eggs.
2009,
Pubmed
,
Xenbase Hellsten,
Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis.
2007,
Pubmed
,
Xenbase Henderson,
The chromosomal location of ribosomal DNA in the mouse.
1974,
Pubmed Henderson,
Location of ribosomal DNA in the human chromosome complement.
1972,
Pubmed Hernandez-Verdun,
Nucleolus: from structure to dynamics.
2006,
Pubmed Honjo,
Preferential transcription of Xenopus laevis ribosomal RNA in interspecies hybrids between Xenopus laevis and Xenopus mulleri.
1973,
Pubmed
,
Xenbase Keller,
Ribosomal DNA in the grasshopper Podisma pedestris: escape from concerted evolution.
2006,
Pubmed Kobayashi,
Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats.
2005,
Pubmed Kotseruba,
Uniparental loss of ribosomal DNA in the allotetraploid grass Zingeria trichopoda (2n = 8).
2003,
Pubmed Kumar,
Chromosomal localization and copy number of 18S + 28S ribosomal RNA genes in evolutionarily diverse mosquitoes (Diptera, Culicidae).
1990,
Pubmed Labhart,
DNA sequences for typical ribosomal gene spacers from Xenopus laevis and Xenopus borealis.
1987,
Pubmed
,
Xenbase Leung,
Bioinformatic analysis of the nucleolus.
2003,
Pubmed Leung,
The dynamics of the nucleolus.
2003,
Pubmed Li,
The chromatin remodeling complex NoRC controls replication timing of rRNA genes.
2005,
Pubmed Louis,
Pichia sorbitophila, an Interspecies Yeast Hybrid, Reveals Early Steps of Genome Resolution After Polyploidization.
2012,
Pubmed MacKenzie,
Ribosomes specifically bind to mammalian mitochondria via protease-sensitive proteins on the outer membrane.
2004,
Pubmed Maggi,
Nucleolar adaptation in human cancer.
2005,
Pubmed Mais,
On the formation of amplified nucleoli during early Xenopus oogenesis.
2002,
Pubmed
,
Xenbase Maleszka,
Yeasts have a four-fold variation in ribosomal DNA copy number.
1993,
Pubmed Malinska,
Similar patterns of rDNA evolution in synthetic and recently formed natural populations of Tragopogon (Asteraceae) allotetraploids.
2010,
Pubmed Malone,
Sterility and gene expression in hybrid males of Xenopus laevis and X. muelleri.
2007,
Pubmed
,
Xenbase Malone,
Physiological sex predicts hybrid sterility regardless of genotype.
2008,
Pubmed
,
Xenbase Maluszynska,
Ribosomal RNA genes in B chromosomes of Crepis capillaris detected by non-radioactive in situ hybridization.
1989,
Pubmed Maxwell,
The small nucleolar RNAs.
1995,
Pubmed Michalak,
Evidence for maternal imprinting of 45S ribosomal RNA genes in Xenopus hybrids.
2014,
Pubmed
,
Xenbase Montanaro,
Nucleolus, ribosomes, and cancer.
2008,
Pubmed Mougey,
Virtually the entire Xenopus laevis rDNA multikilobase intergenic spacer serves to stimulate polymerase I transcription.
1996,
Pubmed
,
Xenbase Muller,
Replication of yeast rDNA initiates downstream of transcriptionally active genes.
2000,
Pubmed Olson,
Conventional and nonconventional roles of the nucleolus.
2002,
Pubmed Olson,
The nucleolus: an old factory with unexpected capabilities.
2000,
Pubmed Pardo-Manuel de Villena,
Natural selection and the function of genome imprinting: beyond the silenced minority.
2000,
Pubmed Peng,
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability.
2007,
Pubmed Pereira,
Cdc14 phosphatase resolves the rDNA segregation delay.
2004,
Pubmed Poccia,
Remodeling of nucleoproteins during gametogenesis, fertilization, and early development.
1986,
Pubmed Reeder,
Spacer regulation of Xenopus ribosomal gene transcription: competition in oocytes.
1983,
Pubmed
,
Xenbase Ruiz-Estévez,
B-chromosome ribosomal DNA is functional in the grasshopper Eyprepocnemis plorans.
2012,
Pubmed Stimpson,
Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.
2014,
Pubmed Strunnikov,
A case of selfish nucleolar segregation.
2005,
Pubmed Stults,
Genomic architecture and inheritance of human ribosomal RNA gene clusters.
2008,
Pubmed Stults,
Human rRNA gene clusters are recombinational hotspots in cancer.
2009,
Pubmed Sullivan,
Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase.
2004,
Pubmed Thiébaud,
Quantitative determination of amplified rDNA and its distribution during oogenesis in Xenopus laevis.
1979,
Pubmed
,
Xenbase Tycowski,
A mammalian gene with introns instead of exons generating stable RNA products.
1996,
Pubmed Uno,
Homoeologous chromosomes of Xenopus laevis are highly conserved after whole-genome duplication.
2013,
Pubmed
,
Xenbase Wallace,
Ribosomal cistrons and the nucleolar organizer.
1966,
Pubmed Walmsley,
Replicon size of yeast ribosomal DNA.
1984,
Pubmed Wang,
Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase.
2004,
Pubmed Wensink,
Denaturation map of the ribosomal DNA of Xenopus laevis.
1971,
Pubmed
,
Xenbase Wiesendanger,
Replication fork barriers in the Xenopus rDNA.
1994,
Pubmed
,
Xenbase Yoshida,
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.
2014,
Pubmed Zhang,
A family of selfish minicircular chromosomes with jumbled chloroplast gene fragments from a dinoflagellate.
2001,
Pubmed Zhou,
The pattern of R2 retrotransposon activity in natural populations of Drosophila simulans reflects the dynamic nature of the rDNA locus.
2009,
Pubmed
