Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Neural Regen Res
2016 Mar 01;113:357-62. doi: 10.4103/1673-5374.179030.
Show Gene links
Show Anatomy links
Matrix metalloproteinases in neural development: a phylogenetically diverse perspective.
Small CD, Crawford BD.
???displayArticle.abstract???
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases originally characterized as secreted proteases responsible for degrading extracellular matrix proteins. Their canonical role in matrix remodelling is of significant importance in neural development and regeneration, but emerging roles for MMPs, especially in signal transduction pathways, are also of obvious importance in a neural context. Misregulation of MMP activity is a hallmark of many neuropathologies, and members of every branch of the MMP family have been implicated in aspects of neural development and disease. However, while extraordinary research efforts have been made to elucidate the molecular mechanisms involving MMPs, methodological constraints and complexities of the research models have impeded progress. Here we discuss the current state of our understanding of the roles of MMPs in neural development using recent examples and advocate a phylogenetically diverse approach to MMP research as a means to both circumvent the challenges associated with specific model organisms, and to provide a broader evolutionary context from which to synthesize an understanding of the underlying biology.
Agrawal,
MMPs in the central nervous system: where the good guys go bad.
2008, Pubmed
Agrawal,
MMPs in the central nervous system: where the good guys go bad.
2008,
Pubmed Ahrens,
Whole-brain functional imaging at cellular resolution using light-sheet microscopy.
2013,
Pubmed Amano,
The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain.
2005,
Pubmed
,
Xenbase Angerer,
Sea urchin metalloproteases: a genomic survey of the BMP-1/tolloid-like, MMP and ADAM families.
2006,
Pubmed Apte,
Metalloproteinases: A parade of functions in matrix biology and an outlook for the future.
2015,
Pubmed Ariza-Cosano,
sox21a directs lateral line patterning by modulating FGF signaling.
2015,
Pubmed Atkinson,
Sensory hair cell development and regeneration: similarities and differences.
2015,
Pubmed Brew,
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
2010,
Pubmed Bruschi,
The significance of matrix metalloproteinases in parasitic infections involving the central nervous system.
2013,
Pubmed Buckley,
Matrix metalloproteinase function in non-mammalian model organisms.
2015,
Pubmed Buhler,
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis.
2009,
Pubmed Caley,
Metalloproteinases and Wound Healing.
2015,
Pubmed Crawford,
Mmp25β facilitates elongation of sensory neurons during zebrafish development.
2014,
Pubmed Crawford,
Ontogeny and regulation of matrix metalloproteinase activity in the zebrafish embryo by in vitro and in vivo zymography.
2005,
Pubmed Dityatev,
The dual role of the extracellular matrix in synaptic plasticity and homeostasis.
2010,
Pubmed Feierstein,
Seeing the whole picture: A comprehensive imaging approach to functional mapping of circuits in behaving zebrafish.
2015,
Pubmed Fu,
Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians.
2009,
Pubmed
,
Xenbase Fujioka,
Neural functions of matrix metalloproteinases: plasticity, neurogenesis, and disease.
2012,
Pubmed Gaublomme,
Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells.
2014,
Pubmed GROSS,
Collagenolytic activity in amphibian tissues: a tissue culture assay.
1962,
Pubmed Hehr,
Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points.
2005,
Pubmed
,
Xenbase Huntley,
Synaptic circuit remodelling by matrix metalloproteinases in health and disease.
2012,
Pubmed Huxley-Jones,
The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio.
2007,
Pubmed Hynes,
The evolution of metazoan extracellular matrix.
2012,
Pubmed Ito,
Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.
2007,
Pubmed Iyer,
The history of matrix metalloproteinases: milestones, myths, and misperceptions.
2012,
Pubmed Jackson,
Update of human and mouse matrix metalloproteinase families.
2010,
Pubmed Janssens,
Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development.
2013,
Pubmed Jin,
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.
2011,
Pubmed Kandasamy,
Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix.
2010,
Pubmed Keow,
Differential in vivo zymography: a method for observing matrix metalloproteinase activity in the zebrafish embryo.
2011,
Pubmed
,
Xenbase Kessenbrock,
Matrix metalloproteinases in stem cell regulation and cancer.
2015,
Pubmed Kim,
Role of matrix metalloproteinase-3 in neurodegeneration.
2011,
Pubmed Kuo,
Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.
2005,
Pubmed Larsen,
Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
2006,
Pubmed Larsen,
The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation.
2004,
Pubmed Le,
Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.
2012,
Pubmed Lee,
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.
2014,
Pubmed Lenglet,
Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke.
2014,
Pubmed Liao,
Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration.
2015,
Pubmed Llano,
Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.
2002,
Pubmed Maidment,
Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activity.
1999,
Pubmed Markovic,
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
2009,
Pubmed Massova,
Matrix metalloproteinases: structures, evolution, and diversification.
1998,
Pubmed Monsonego-Ornan,
Matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration.
2012,
Pubmed Myers,
Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.
2011,
Pubmed Nagase,
Structure and function of matrix metalloproteinases and TIMPs.
2006,
Pubmed Nishida,
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.
2008,
Pubmed Oh,
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.
1999,
Pubmed Oh,
Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
2015,
Pubmed Page-McCaw,
Matrix metalloproteinases and the regulation of tissue remodelling.
2007,
Pubmed Page-McCaw,
Remodeling the model organism: matrix metalloproteinase functions in invertebrates.
2008,
Pubmed Porlan,
MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.
2014,
Pubmed Prendergast,
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
2012,
Pubmed Py,
Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.
2014,
Pubmed Roberts,
Learning and memory in zebrafish larvae.
2013,
Pubmed Rodríguez,
Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics.
2010,
Pubmed Thomas,
There and back again: development and regeneration of the zebrafish lateral line system.
2015,
Pubmed Tonge,
Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity.
2013,
Pubmed
,
Xenbase Van Hove,
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
2012,
Pubmed Verslegers,
Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system.
2013,
Pubmed Voelkel,
FGF and Notch signaling in sensory neuron formation: a multifactorial approach to understanding signaling pathway hierarchy.
2014,
Pubmed Wang,
Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.
2010,
Pubmed Werner,
Neural MMP-28 expression precedes myelination during development and peripheral nerve repair.
2007,
Pubmed
,
Xenbase Wyatt,
The zebrafish embryo: a powerful model system for investigating matrix remodeling.
2009,
Pubmed Yong,
Metalloproteinases: mediators of pathology and regeneration in the CNS.
2005,
Pubmed
