XB-ART-52510
Biomed Opt Express
2016 Mar 30;74:1590-603. doi: 10.1364/BOE.7.001590.
Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows.
Zhou KC, Huang BK, Gamm UA, Bhandari V,
Khokha MK , Choma MA.
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We present a new OCT method for flow speed quantification and directional velocimetry: particle streak velocimetry-OCT (PSV-OCT). PSV-OCT generates two-dimensional, 2.5-vector component (vx ,|vy |,vz ) maps of microscale flow velocity fields. Knowledge of 2.5-vector components also enables the estimation of total flow speed. The enabling insight behind PSV-OCT is that tracer particles in sparsely-seeded fluid flow trace out streaks in (x,z,t)-space. The streak orientations in x-t and z-t yield vx and vz , respectively. The in-plane (x-z plane) residence time yields the out-of-plane speed |vy |. Vector component values are generated by fitting streaks to a model of image formation that incorporates equations of motion in 3D space. We demonstrate cross-sectional estimation of (vx ,|vy |,vz ) in two important animal models in ciliary biology: Xenopus embryos (tadpoles) and mouse
trachea .
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27375926
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PMC4929663
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Biomed Opt Express
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References [+] :
Ahn,
Quantification of a three-dimensional velocity vector using spectral-domain Doppler optical coherence tomography.
2007,
Pubmed
Ahn,
Quantification of a three-dimensional velocity vector using spectral-domain Doppler optical coherence tomography.
2007,
Pubmed
Ansari,
Micro-anatomical and functional assessment of ciliated epithelium in mouse trachea using optical coherence phase microscopy.
2015,
Pubmed
Birket,
A functional anatomic defect of the cystic fibrosis airway.
2014,
Pubmed
Chen,
Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media.
1997,
Pubmed
Davis,
Quantitative measurement of blood flow dynamics in embryonic vasculature using spectral Doppler velocimetry.
2009,
Pubmed
Drexler,
Optical coherence tomography today: speed, contrast, and multimodality.
2014,
Pubmed
Gamm,
Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography.
2015,
Pubmed
Haindl,
Total retinal blood flow measurement by three beam Doppler optical coherence tomography.
2016,
Pubmed
Huang,
Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology.
2015,
Pubmed
Huang,
Resolving directional ambiguity in dynamic light scattering-based transverse motion velocimetry in optical coherence tomography.
2014,
Pubmed
Huang,
Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography.
2015,
Pubmed
,
Xenbase
Huang,
Microscale imaging of cilia-driven fluid flow.
2015,
Pubmed
Izatt,
In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography.
1997,
Pubmed
Jonas,
Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry.
2011,
Pubmed
,
Xenbase
Jones,
Measuring hemodynamic changes during mammalian development.
2004,
Pubmed
Lee,
Dynamic light scattering optical coherence tomography.
2012,
Pubmed
Liu,
An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load.
2014,
Pubmed
Liu,
Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography.
2013,
Pubmed
Ma,
Measurement of absolute blood flow velocity in outflow tract of HH18 chicken embryo based on 4D reconstruction using spectral domain optical coherence tomography.
2010,
Pubmed
Makita,
Quantitative retinal-blood flow measurement with three-dimensional vessel geometry determination using ultrahigh-resolution Doppler optical coherence angiography.
2008,
Pubmed
Mujat,
Optical coherence tomography-based micro-particle image velocimetry.
2013,
Pubmed
Oldenburg,
Monitoring airway mucus flow and ciliary activity with optical coherence tomography.
2012,
Pubmed
Qi,
Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography.
2016,
Pubmed
Singh,
Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans.
2010,
Pubmed
Srinivasan,
OCT methods for capillary velocimetry.
2012,
Pubmed
Sun,
Optical coherence elastography: current status and future applications.
2011,
Pubmed
Weiss,
Localized measurement of longitudinal and transverse flow velocities in colloidal suspensions using optical coherence tomography.
2013,
Pubmed
Werner,
Understanding ciliated epithelia: the power of Xenopus.
2012,
Pubmed
,
Xenbase
Zhou,
Erratum: Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows: erratum.
2016,
Pubmed
Zhou,
Improved velocimetry in optical coherence tomography using Bayesian analysis.
2015,
Pubmed
