Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Water pollutants associated with agriculture may contribute to the increased prevalence of infectious diseases caused by ranaviruses. We have established the amphibian Xenopus laevis and the ranavirus Frog Virus 3 (FV3) as a reliable experimental platform for evaluating the effects of common waterborne pollutants, such as the insecticide carbaryl. Following 3 weeks of exposure to 10 ppb carbaryl, X. laevis tadpoles exhibited a marked increase in mortality and accelerated development. Exposure at lower concentrations (0.1 and 1.0 ppb) was not toxic, but it impaired tadpole innate antiviral immune responses, as evidenced by significantly decreased TNF-α, IL-1β, IFN-I, and IFN-III gene expression. The defect in IFN-I and IL-1β gene expression levels persisted after metamorphosis in froglets, whereas only IFN-I gene expression in response to FV3 was attenuated when carbaryl exposure was performed at the adult stage. These findings suggest that the agriculture-associated carbaryl exposure at low but ecologically-relevant concentrations has the potential to induce long term alterations in host-pathogen interactions and antiviral immunity.
Boone,
Examining multiple sublethal contaminants on the gray treefrog (Hyla versicolor): Effects of an insecticide, herbicide, and fertilizer.
2006, Pubmed
Boone,
Examining multiple sublethal contaminants on the gray treefrog (Hyla versicolor): Effects of an insecticide, herbicide, and fertilizer.
2006,
Pubmed Brown,
The interactive effect of an emerging infectious disease and an emerging contaminant on Woodhouse's toad (Anaxyrus woodhousii) tadpoles.
2013,
Pubmed Buck,
Effects of Pesticide Mixtures on Host-Pathogen Dynamics of the Amphibian Chytrid Fungus.
2015,
Pubmed Bulen,
Carbaryl concentration gradients in realistic environments and their influence on our understanding of the tadpole food web.
2011,
Pubmed Carey,
Possible interrelations among environmental toxicants, amphibian development, and decline of amphibian populations.
1995,
Pubmed Chen,
Antiviral immunity in amphibians.
2011,
Pubmed
,
Xenbase Christin,
Effects of agricultural pesticides on the immune system of Rana pipiens and on its resistance to parasitic infection.
2003,
Pubmed Davidson,
Effects of chytrid and carbaryl exposure on survival, growth and skin peptide defenses in foothill yellow-legged frogs.
2007,
Pubmed De Jesús Andino,
Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.
2012,
Pubmed
,
Xenbase Durbin,
Type I IFN modulates innate and specific antiviral immunity.
2000,
Pubmed Edholm,
Nonclassical MHC-Restricted Invariant Vα6 T Cells Are Critical for Efficient Early Innate Antiviral Immunity in the Amphibian Xenopus laevis.
2015,
Pubmed
,
Xenbase Fattahi,
The effect of Carbaryl on the pituitary-gonad axis in male rats.
2012,
Pubmed Fujino,
Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.
2016,
Pubmed Grayfer,
Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus.
2015,
Pubmed
,
Xenbase Grayfer,
The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity.
2014,
Pubmed
,
Xenbase Hayes,
Pesticide mixtures, endocrine disruption, and amphibian declines: are we underestimating the impact?
2006,
Pubmed
,
Xenbase Houlahan,
Quantitative evidence for global amphibian population declines.
2000,
Pubmed Igarashi,
Effects of possible endocrine disrupting chemicals on bacterial component-induced activation of NF-kappaB.
2006,
Pubmed Kerby,
Combined effects of atrazine and chlorpyrifos on susceptibility of the tiger salamander to Ambystoma tigrinum virus.
2009,
Pubmed Mnif,
Effect of endocrine disruptor pesticides: a review.
2011,
Pubmed Morales,
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
2010,
Pubmed
,
Xenbase Müller,
Functional role of type I and type II interferons in antiviral defense.
1994,
Pubmed Ohnishi,
Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.
2008,
Pubmed Peter,
Carbaryl exposure and recovery modify the interrenal and thyroidal activities and the mitochondria-rich cell function in the climbing perch Anabas testudineus Bloch.
2013,
Pubmed Pope,
Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action.
2005,
Pubmed Relyea,
A cocktail of contaminants: how mixtures of pesticides at low concentrations affect aquatic communities.
2009,
Pubmed Robert,
Comparative and developmental study of the immune system in Xenopus.
2009,
Pubmed
,
Xenbase Rollins-Smith,
Metamorphosis and the amphibian immune system.
1998,
Pubmed Serpa,
Assessment of river water quality using an integrated physicochemical, biological and ecotoxicological approach.
2014,
Pubmed Sifkarovski,
Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis.
2014,
Pubmed
,
Xenbase Smalling,
Pesticide concentrations in frog tissue and wetland habitats in a landscape dominated by agriculture.
2015,
Pubmed Wen,
Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α.
2016,
Pubmed
,
Xenbase
