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Rouxs Arch Dev Biol
1990 Mar 01;1986:330-335. doi: 10.1007/BF00383771.
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Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).
Asashima M, Nakano H, Shimada K, Kinoshita K, Ishii K, Shibai H, Ueno N.
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Recently the mesoderm-inducing effects of the transforming growth factor β (TGF-β) family of proteins have been widely examined. In an attemt to elucidate the functions of these proteins, porcine inhibin A and activin A (erythroid differentiation factor; EDF) were examined. Treatment of explants with activin A led to differentiation of mesodermal derivatives such as mesenchyme, notochord, blood cells and muscle, but inhibin A had a much lesser effect. The mesodermal differentiation induced by activin A was also comfirmed by analyses using a polyclonal antibody against muscle myosin. By indirect immunofluorescence analysis, the differentiation of muscle blocks was observed in the activin-A-treated explants, whereas no differentiation was observed in inhibin-A-treated and control explants. These findings confirm that this protein of the TGF-β family has mesoderm-inducing ability.
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