Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Antibodies directed to fibronectin (anti-FN) were injected into the blastocoel of late blastulae of Xenopus laevis. Two animal caps (ectoderm) were isolated, when control embryos reached the early gastrula stage, and were combined with untreated upper blastopore lip in the sandwich method. In two control series fibronectin or Holtfreter solution was injected into the blastocoel. The results of the experiments suggest that neural induction cannot be prevented by binding anti-FN to fibronectin, which covers the blastocoelic side of the ectoderm. The data support the view that extracellular matrix proteins are not themselves responsible for neural induction. However, in comparison with the control series a slight shift of the differentiation pattern in the spinocaudal direction could be observed in the anti-FN series. The possible role of extracellular proteins in the formation of a close juxtaposition of mesodermal and ectodermal target cells as a prerequisite for shortdistance transmission of neural inducers is discussed.
Asashima,
Effects of inducers on inner and outer gastrula ectoderm layers of Xenopus laevis.
1983, Pubmed,
Xenbase
Asashima,
Effects of inducers on inner and outer gastrula ectoderm layers of Xenopus laevis.
1983,
Pubmed
,
Xenbase Born,
Covalent coupling of neuralizing factors from Xenopus to Sepharose beads: no decrease of inducing activity.
1986,
Pubmed
,
Xenbase Boucaut,
Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.
1984,
Pubmed Boucaut,
Fibronectin in early amphibian embryos. Migrating mesodermal cells contact fibronectin established prior to gastrulation.
1983,
Pubmed Boucaut,
Evidence for the role of fibronectin in amphibian gastrulation.
1985,
Pubmed Boucaut,
Prevention of gastrulation but not neurulation by antibodies to fibronectin in amphibian embryos.
,
Pubmed Critchley,
Distribution of fibronectin in the ectoderm of gastrulating chick embryos.
1979,
Pubmed Darribère,
Synthesis and distribution of laminin-related polypeptides in early amphibian embryos.
1986,
Pubmed Darribère,
Fibronectin synthesis during oogenesis and early development of the amphibian Pleurodeles waltlii.
1984,
Pubmed Duband,
Distribution of fibronectin in the early phase of avian cephalic neural crest cell migration.
1982,
Pubmed Duband,
Appearance and distribution of fibronectin during chick embryo gastrulation and neurulation.
1982,
Pubmed Duprat,
Extracellular matrix and neural determination during amphibian gastrulation.
1984,
Pubmed Gimlich,
Improved fluorescent compounds for tracing cell lineage.
1985,
Pubmed
,
Xenbase Grunz,
Cell contacts between chorda-mesoderm and the overlaying neuroectoderm (presumptive central nervous system) during the period of primary embryonic induction in amphibians.
1979,
Pubmed Grunz,
Information transfer during embryonic induction in amphibians.
1985,
Pubmed
,
Xenbase John,
Neural induction in amphibians : Transmission of a neuralizing factor.
1983,
Pubmed Lee,
Temporal and spatial regulation of fibronectin in early Xenopus development.
1984,
Pubmed
,
Xenbase Nakatsuji,
Experimental manipulation of a contact guidance system in amphibian gastrulation by mechanical tension.
,
Pubmed Nakatsuji,
Fibronectin visualized by scanning electron microscopy immunocytochemistry on the substratum for cell migration in Xenopus laevis gastrulae.
1985,
Pubmed
,
Xenbase SAXEN,
Transfilter neural induction of amphibian ectoderm.
1961,
Pubmed STEEDMAN,
Polyester wax; a new ribboning embedding medium for histology.
1957,
Pubmed Tacke,
Cell contacts between inducing tissue and targets cells during neural induction.
1986,
Pubmed
,
Xenbase Toivonen,
Transmission problem in primary induction.
1979,
Pubmed Toivonen,
Transfilter studies on neural induction in the newt.
1975,
Pubmed Yamada,
Cell surface interactions with extracellular materials.
1983,
Pubmed
